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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 215-185-5 | CAS number: 1310-73-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
NaOH is not expected to be systemically available in the body under normal handling and use conditions and for this reason it can be stated that the substance will not reach the foetus nor reach male and female reproductive organs (EU RAR of sodium hydroxide (2007), section 4.1.2.8, page 73). It can be concluded that a specific study to determine the toxicity to reproduction is not necessary.
Additional information
No valid studies were identified regarding developmental toxicity nor toxicity to reproduction in animals after oral, dermal or inhalation exposure to NaOH (EU RAR, section 4.1.2.8, page 73).
It is not useful to do a reproduction or developmental toxicity test with NaOH in rats because the hazard of sodium for humans has been characterised sufficiently (e.g. Fodor et al., 1999). It is also not useful to study the reproduction/developmental toxicity of hydroxide via an oral study because at high concentrations the substance is corrosive or irritating, while at low concentrations the hydroxide will be neutralised in the stomach by gastric juice, which has a very low pH. Furthermore, oral exposure to NaOH is negligible under normal handling and use condtions and therefore an oral reproduction/developmental toxicity study is inappropriate.
NaOH is not expected to be systemically available in the body under normal handling and use conditions and for this reason it can be stated that the substance will not reach the foetus nor reach male and female reproductive organs. It can be concluded that a specific study to determine the developmental toxicity or the toxicity to reproduction is not necessary.
Short description of key information:
NaOH is not expected to be systemically available in the body under normal handling and use conditions and for this reason it can be stated that the substance will not reach the foetus nor reach male and female reproductive organs (EU RAR of sodium hydroxide (2007), section 4.1.2.8, page 73). It can be concluded that a specific study to determine the developmental toxicity or the toxicity to reproduction is not necessary.
Effects on developmental toxicity
Description of key information
NaOH is not expected to be systemically available in the body under normal handling and use conditions and for this reason it can be stated that the substance will not reach the foetus nor reach male and female reproductive organs (EU RAR of sodium hydroxide (2007), section 4.1.2.8, page 73). It can be concluded that a specific study to determine the developmental toxicity or the toxicity to reproduction is not necessary.
Justification for classification or non-classification
Classification for reproductive or developmental toxicity is not necessary since NaOH is not expected to be systemically available in the body under normal handling and use conditions and the substance will not reach the foetus nor reach male and female reproductive organs (EU RAR of sodium hydroxide (2007), section 4.1.2.8, page 73).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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