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Diss Factsheets
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EC number: 219-941-5 | CAS number: 2579-20-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 May 2005-23 January 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to international guidelines and GLP standards.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 1,3-Cyclohexanedimethanamine
- EC Number:
- 219-941-5
- EC Name:
- 1,3-Cyclohexanedimethanamine
- Cas Number:
- 2579-20-6
- Molecular formula:
- C8H18N2
- IUPAC Name:
- 1,3-Cyclohexanedimethanamine
- Details on test material:
- - Name of test material (as cited in study report): 1,3-Bis(aminomethyl)cyclohexane
- Physical state: liquid
- Stability under test conditions: confirmed stable (IR spectrophotometry)
- Storage condition of test material: Refrigeration (actual temperature: 2.8°C to 8.4°C, permissible range: 1°C to 10°C), shielded from light, nitrogen-sealed
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 8 to 9 weeks
- Weight at study initiation: 179-199g
- Fasting period before study: 17 hours before to 3 hours after administration
- Housing:Autoclave-sterilized polycarbonate cages (265W×426D×200H mm, Tokiwa Kagaku Kikai Co., Ltd.) were used and replaced on the day of grouping and Day 8. The cages for the animals in the second administration group were also replaced on the day before the administration. Animals were housed 4 animals per cage before grouping, and 3 animals per cage thereafter.
- Diet: ad libitum
- Water: ad libitum
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.0-22.6
- Humidity (%): 51.5-66.5
- Air changes (per hr): 6 to 20 times per hour
- Photoperiod (hrs dark / hrs light): 12 hours/day
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose:Three females were subjected to each dosing. According to information obtained from the test substance supplier (manufacturer), the approximate lethal dose 50% (LD50) for male rats is 700 mg/kg. Accordingly, the dose level for the first administration was set at 300 mg/kg, and this study was conducted in accordance with the GHS flow chart. - Doses:
- 300 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 females per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:before dosing, and post dosing: 10 min, 30 min, 1 hour, 3 hours, 6 hours. Body weights recorded prior to dosing,and on days 4, 8, and 15.
- Necropsy of survivors performed: no survivors
- Other examinations performed: clinical signs, body weight, pathological examination/necropsy - Statistics:
- Not Applicable
Results and discussion
- Preliminary study:
- Not Applicable
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD100
- Effect level:
- 2 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - ca. 2 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- > 300 mg/kg bw
- Mortality:
- In the first and second administration at 300 mg/kg, no deaths or abnormalities in clinical signs were observed.
At the third administration at 2000 mg/kg, one animal died on Day 1 (day of administration), and two animals died on Day 2. - Clinical signs:
- other: In the first and second administration at 300 mg/kg, no abnormalities in clinical signs were observed. At the third administration at 2000 mg/kg, decreases in locomotor activity and irregular respiration were noted in all animals from 10 minutes after th
- Gross pathology:
- No abnormalities were noted in the first or second administration at 300 mg/kg.
In all dead animals, reddish change and edema were noted in the forestomach and glandular stomach, and abnormal contents were observed in the stomach and intestine. Moreover, reddish ascites was noted in the abdominal cavity in the animal found dead on the day of administration. - Other findings:
- Not applicable
Any other information on results incl. tables
Not applicable
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- 1,3-BAC was classified into Category 4 (>300-2000 mg/kg b.w.) in accordance with the Globally Harmonized Classification System (GHS), under the conditions of this study.
- Executive summary:
This study was conducted to assess the acute toxicity of 1,3-BAC in female rats administered by oral gavage at the single doses of 300 mg/kg (first and second administration) and 2000 mg/kg (third administration).
At the third administration at 2000 mg/kg, decreases in locomotor activity, ptosis, hypothermia, and abnormalities in respiration and posture were observed, and all animals died by Day 2. In necropsy, abnormalities in the stomach and intestine were observed. The changes in the stomach and intestine were considered to be attributed to irritation caused by the test substance. In the first and second administration at 300 mg/kg, no deaths or abnormalities attributed to the test substance were observed in the clinical signs, body weight, or necropsy findings.
Therefore, 1,3-BAC was classified into Category 4 (>300-2000 mg/kg b.w.) in accordance with the Globally Harmonized Classification System (GHS), under the conditions of this study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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