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Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1997
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
according to guideline
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)
GLP compliance:
yes
Analytical monitoring:
not specified
Test organisms (species):
Daphnia magna
Test type:
not specified
Water media type:
freshwater
Limit test:
no
Total exposure duration:
21 d
Test temperature:
19.2-20.9 °C
pH:
5.5-7.9
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
16 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
42 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction

Since no details on analytical monitoring are given, it is assumed that the results relate to nominal concentrations, based on test substance concentrations.

Executive summary:

The long-term toxicity of phthalic anhydride to aquatic invertebrates was determined in a test conducted according to OECD Guideline 211 (Daphnia magna Reproduction Test). A 21d-NOEC of 16 mg/L was obtained. (MITI, 2003)

Description of key information

The long-term toxicity of phthalic anhydride to aquatic invertebrates was

determined in a test conducted according to OECD Guideline 211 (Daphnia magna Reproduction Test). A 21d-NOEC of 16 mg/L was obtained. The result is regarded with caution, since it cannot be excluded that the toxicity observed was due to pH effects based on the formation of phthalic acid during the experiment causing a pH shift. (MITI, 2003).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
NOEC
Effect concentration:
16 mg/L

Additional information

There is only one long-term toxicity test towards aquatic invertebrates available. As no information is given on pH, it cannot be excluded that the toxicity observed was due to pH effects. A weight of evidence approach is applied, as the study is stated to be reliable, but should only be taken into account applying an appropriate assessment factor for PNEC derivation.