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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No guideline specified in the study report. Non GLP-Study. Documentation sufficient.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The purpose of this test was to determine an approximate lethal dose (ALD) of H-25285 when administered as a single oral dose to male rats. The ALD was defined as the lowest dose administered which caused death either on the day of dosing or within 14 days post exposure.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- H-25285 was administered as a single oral dose by intragastric intubation to male rats.
- Doses:
- 450, 670, 1000, 1500, 2300, and 3400 mg/kg
- No. of animals per sex per dose:
- 1
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 670 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
The lowest dose of H-25285 which resulted in the death of a test animal was 670 mg/kg. The survival of rats dosed at 1000 or 1500 mg/kg is attributed to animal variability. The dose regimen and the mortality resulting over the 15-day test period are detailed below.
Dose (mg/kg) Volume (mL) Suspension Concentration (mg/mL) Initial Body Weight (g) Mortality
450 0.29 350 226.0 No
670 0.84 150 188.5 Yes
1000 0.59 350 204.9 No
1500 0.93 350 216.7 No
2300 2.9 150 191.1 Yes
3400 2.3 350 237.4 Yes
The rat dosed at 450 mg/kg exhibited no clinical signs or body weight loss during the study. The rat dosed at 1000 mg/kg exhibited brown nasal discharge on test day 3 and body weight loss of approximately 19% of initial weight by 4 days after dosing. The rat dosed at 1500 mg/kg exhibited wet chin on the day of dosing and brown nasal discharge on test day 5. This rat also had weight loss of approximately 20% of initial weight by 6 days after dosing.
Lethal Doses
Dry brown nasal discharge and yellow stained perineum were observed up to 5 days after dosing in the rat dosed at 670 mg/kg. The rat dosed at 2300 mg/kg exhibited lethargy, prostrate posture, dry red oral discharge, and wet or yellow-stained perineum by 2 days after dosing. The rat dosed at 3400 mg/kg exhibited red ocular discharge and yellow stained perineum on test day 3.
Applicant's summary and conclusion
- Interpretation of results:
- moderately toxic
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of this study, the oral ALD for H-25285 was 670 mg/kg of body weight. This substance is considered to be slightly toxic (ALD 500 - 5000 mg/kg) when administered as a single oral dose to male rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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