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EC number: 239-364-2 | CAS number: 15336-18-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 August 1989 to 03 September 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 15336-18-2
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Ammonium hexachlororhodate
- Substance type: red-coloured powder
- Physical state: solid
- Analytical purity: No data
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: “Assay: 29.39%” [presumably percentage of rhodium].
- Lot/batch No.: S071559
- Expiration date of the lot/batch: no data
- Stability under test conditions: not determined
- Storage condition of test material: in a plastic flip-top jar at room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: David Percival Ltd, Moston, Sandbach, Cheshire, UK.
- Age at study initiation: approximately 12-16 weeks
- Weight at study initiation: 2.52-2.70 kg
- Housing: Individually in suspended metal cages
- Diet (e.g. ad libitum): ad libitum “Rabbit Diet” from Preston Farmers Limited, New Leake, Boston, Lincolnshire, UK
- Water (e.g. ad libitum): ad libitum mains drinking water
- Acclimation period: minimum 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16-20
- Humidity (%): 62-68 [relative]
- Air changes (per hr): approximately 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To:
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
Amount(s) applied (volume or weight with unit): 0.5 g
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- Three males
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm x 2.5 cm [6.25 cm2]
- Type of wrap if used: material was placed under a gauze patch secured in place with a strip of surgical adhesive tape (BLENDERM, approximate size 2.5x4.0 cm). An elasticated corset (TUBIGRIP) was applied over this, around the trunk of the animal.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes (gentle swabbing with cotton wool soaked in distilled water)
- Time after start of exposure: 4 hours
SCORING SYSTEM: Erythema and eschar formation, and oedema formation, were assessed approximately one, 24, 48 and 72 hours after removal of the patches. A primary irritation index was calculated by adding all of the 24- and 72-hour readings (scored using the Draize scale, see “Any other information”) and dividing by the total number of observations (i.e. six). According to the study report, a primary irritation index of zero indicates a “non-irritant”; one of >0-2 indicates a “mild irritant”; one of >2-5 indicates a moderate irritant and one of >5-8 indicates a severe irritant.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hours after patch removal
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: not applicable
- Remarks on result:
- other: see below
- Irritant / corrosive response data:
- No evidence of skin irritation. See attchment.
Yellow-orange staining of the skin caused by the test material was observed. Nevertheless, it was reported that this did not prevent accurate assessment of the skin responses, particularly erythema and eschar formation, for which scores of 0 for all rabbits at all time points were recorded. The study was terminated 72 hours after removal of the patches because of the lack of adverse skin reactions. - Other effects:
- No other effects or systemic toxicity were reported.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a guideline study, to GLP, ammonium hexachlororhodate produced a primary irritation index of 0 following a 4-hr semi-occlusive application (0.5 g) to the skin of three rabbits. No corrosive effects or evidence of systemic toxicity were reported.
- Executive summary:
In an OECD Test Guideline 404 study, ammonium hexachlororhodate was investigated for irritant (and corrosive) effects following a 4-hr (semi-occluded) application (0.5 g) to the shaved, intact skin of three male White Russian rabbits. The test sites were quantitatively and qualitatively assessed for erythema (and eschar) formation and oedema 1, 24, 48 and 72 hrs after removal of the patches.
No erythema or eschar formation, or oedema, was seen at any time point in any animal. A primary dermal irritation index of 0 was calculated using the observations at 24 and 72 hr. Yellow-orange staining of the skin caused by the test material was observed. Nevertheless, it was reported that this did not prevent accurate assessment of the skin responses. No other effects or systemic toxicity were reported.
Based on the results of this study, no classification for skin irritation is required according to EU CLP criteria (EC 1272/2008).
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