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EC number: 204-274-4 | CAS number: 118-75-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: All information on this study is derived from the review article BUA Report 85, as the complete study report is not at hand. The testing laboratory report no. is 6690-68/04
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- BUA Report 85, Ref. Hazleton 1991
- Author:
- Beratergremium für umweltrelevante Altstoffe der Gesellschaft Deutscher Chemiker (BUA)
- Year:
- 1 992
- Bibliographic source:
- Hirzel Verlag, Stuttgart
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- Remarks:
- as only the respective review article is at hand
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tetrachloro-p-benzoquinone
- EC Number:
- 204-274-4
- EC Name:
- Tetrachloro-p-benzoquinone
- Cas Number:
- 118-75-2
- Molecular formula:
- C6Cl4O2
- IUPAC Name:
- 2,3,5,6-tetrachloro-1,4-benzoquinone
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD(SD)BR-strain
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- gravimetrically determined mean aerosol concentration: 2.485 mg/L air = 2485 mg/m3
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 2.485 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: The dust aerosol concentration of 2.485 mg/L air was gravimetrically determined. 95% CL could not be determined, as only 1 aerosol concentration was tested.
- Mortality:
- 50 % (sex was not specified in the review article)
- Clinical signs:
- other: stringy fur, apathy, cool skin surface, bodily discolouring and respiratory distress lasting in a few animals until the second observation week.
- Body weight:
- Body weight gain was reduced in the survivors during observation week 1 (post inhalation exposure).
- Gross pathology:
- Macroscopic alterations in upper respiratory tract and lungs in decedent animals. No noteworthy findings in the survivors at 14 days post inhalation exposure.
- Other findings:
- Increased lung weights in decedent animals.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Head-nose inhalation exposure of male and female rats to 2,3,5,6-tetrachloro-1,4-benzoquinone for 4 hours at a gravimetrically determined mean dust aerosol concentration of 2.485 mg/L air led to the premature death of 5 of 10 animals. Therefore, 2.485 mg/L air was assumed to represent an approximate LC50 (4 hours) for 2,3,5,6-tetrachloro-1,4-benzoquinone.
- Executive summary:
2,3,5,6-tetrachloro-1,4-benzoquinone was tested for inhalation toxicity similar to OECD Guideline 403. Reliability grade 4 (reliability not assignable) was assigned to the study, as all information on this study was attained only from a review article. Over a period of 4 hours, five male and five female rats were exposed nose/head only to the test substance at a mean gravimetrically determined dust aerosol concentration of 2.485 mg/L air. The exposure was followed by a 14-day observation period. Mortality, bodyweights, clinical signs and gross necropsy findings were recorded and lung weights were determined. The attained "average particle diameter" of the generated dust aerosol [(probably meaning "average Mass Median Aerodynamic Diameter (MMAD)"] of 1.76 µm was well within the range of 1 to 4 µm MMAD recommended for acute inhalation toxicity testing in rats by various technical guidelines, e.g. EPA OPPTS 870.1300. Therefore, adequate exposure to the test substance over the whole respiratory tract can be assumed.
Exposure to the test substance induced 50% mortality, i.e. the premature death of 5 of 10 animals. Clinical signs comprised stringy fur, apathy, cool skin surface, bodily discolouring and respiratory distress lasting in a few animals until the second observation week. Retardation of body weight gain was evident in the survivors during observation week 1. Necropsy revealed alterations in the upper respiratory tract and lungs as well as increased lung weights in decedent animals, but no noteworthy findings were evident in the survivors at their scheduled necropsy 14 days post exposure.
In view of the 50% mortality attained, 2.485 mg/L air was assumed to represent an approximate LC50(4 hours) for 2,3,5,6-tetrachloro-1,4-benzoquinone.
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