Registration Dossier
Registration Dossier
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EC number: 204-171-4 | CAS number: 117-08-8
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: case reports
Data source
Reference
- Reference Type:
- publication
- Title:
- Occupational asthma due to tetrachlorophthalic anhydride
- Author:
- Schlueter DP, Banaszak EF, Fink JN, Barboriak J
- Year:
- 1 978
- Bibliographic source:
- J Occup Med 20, 183-188
Materials and methods
- Type of sensitisation studied:
- respiratory
- Study type:
- case report
- Principles of method if other than guideline:
- The patient underwent a complete history and physical examination and routine laboratory studies including chest-x-ray, -ectg, hemogram, chemistry profile, sputum cultures and pulmonary function studies. Inhalation challenge with TCPA was performed to detect hypersensitivity reaction and immunologic studies were performed to demonstrate precipitating or specific IgE antibodies in the workers.
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetrachlorophthalic anhydride
- EC Number:
- 204-171-4
- EC Name:
- Tetrachlorophthalic anhydride
- Cas Number:
- 117-08-8
- Molecular formula:
- C8Cl4O3
- IUPAC Name:
- tetrachloro-1,3-dihydro-2-benzofuran-1,3-dione
Constituent 1
Method
- Type of population:
- occupational
- Controls:
- no data
- Route of administration:
- inhalation
Results and discussion
- Results of examinations:
- Inhalation challenge with TCPA reproduced the symptoms and demonstrated both an immeditate and late (4-6 hours) physiologic response.
Any other information on results incl. tables
Although the clinical picture strongly suggested a hypersensitivity reaction, immunologic studies failed to demonstrate precipitating or specific IgE antibody. Avoidance of exposure resulted in resolution of symptoms; however, three of the five individuals had residual functional impairment.
Applicant's summary and conclusion
- Executive summary:
Five workers are reported who were involved in the production of exoxy resins and developed recurrent respiratory symptoms and physiologic abnormalities following exposure to tetrachlorophthalic anhydride (TCPA). Inhalation challenge with TCPA reproduced the symptoms and demonstrated both an immeditate and late (4-6 hours) physiologic response.
Although the clinical picture strongly suggested a hypersensitivity reaction, immunologic studies failed to demonstrate precipitating or specific IgE antibody. Avoidance of exposure resulted in resolution of symptoms; however, three of the five individuals had residual functional impairment.
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