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EC number: 606-744-8 | CAS number: 213464-77-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
The 96-hour LC50 value for the Rainbow trout fish exposed to IR5878 was greater than 122 mg/L, the highest concentration tested. No mortalities or toxic effects were observed in Rainbow trout exposed to IR5878 at concentrations up to 122 mg/L. The 96-hour no mortality concentration and the NOEC were 122 mg/L.
The 96-hour NOEC and the 96-hour LC0 of IR5878 to Zebra fish were determined to be at least 100 mg/L. The 96-hour LOEC , the 96-hour LC50 and the 96-hour LC100 were clearly higher than 100 mg/L.
The 96-hour LC50 value for the Bluegill fish exposed to IR5878 was greater than 142 mg/L, the highest concentration tested. No mortalities or toxic effects were observed in Bluegill exposed to IR5878 at concentrations up to 142 mg/L. The 96-hour no mortality concentration and the NOEC were 142 mg/L.
A study was performed to evaluate the influence of IR5878 on the mobility respectively survival ofDaphnia magna. Groups of 20 youngDaphnia magnawere exposed in a static test for 48 hours to an aqueous test medium containing IR5878 at concentrations of 0,12.5, 25, 50 and 100 mg/L. The 24-hour EC0of IR5878 was 50 mg/L. The 24-hour EC50of IR5878 were clearly higher than 100 mg/L. The 24-hour EC100of IR5878 were clearly higher than 100 mg/L. The 48-hour EC0of IR5878 was 50 mg/L. The 48-hour EC50of IR5878 were clearly higher than 100 mg/L. The 48-hour EC100of IR5878 were clearly higher than 100 mg/L. The NOEC of IR5878 was 50 mg/L.
A study was performed to evaluate the influence of IR5878 on survival of 3-4 days old larvae ofChironomus riparius. In a limit test 4 groups of 5 first instar larvae ofChironomus ripariuswere exposed to IR5878 at the nominal concentration of 100 mg/L for 48 hours. 4 additional groups of 5 animals where used as control. The 48-hour NOEC and EC0of IR5878 to the larvae ofChironomus ripariuswere determined to be at least 100 mg/L (the only tested concentration). The 48-hour LOEC and the 48-hour EC50were clearly higher than 100 mg/L. These values could not be quantified due to the absence of toxicity of IR5878 up to the highest test concentration.
A study was performed to determine the toxicity of IR5878 to the red swamp crayfish (Procambarus clarkii) during a 96-hour exposure period under static test conditions. Crayfish were exposed to a geometric series of five test concentrations (7.5, 15, 30, 60 and 120 mg IR5878/L) and a negative (dilution water) control. The 96-hour LC50value for the Crayfish (Procambarus clarkii) exposed to IR5878 was greater than 129 mg/L, the highest concentration tested. No mortalities or effects were observed in Crayfish exposed to IR5878 at concentrations up to 129 mg/L. The 96-hour no mortality concentration and the NOEC were 129 mg/L. Measured tissue concentrations of IR5878 in the Crayfish ranged from below the LOQ up to 1.99 µg a.s./g.
A study was performed to determine the median lethal concentration (LC50) of IR5878 to pond snail (Lymnaea stagnalis). Based on the results of a range finding test, the definitive test was carried out at nominal concentrations of IR5878 of12.5, 25, 50 and 100 mg/L. The test was carried out under static conditions over a 96 hours period. The 96-hour LC50of IR5878 to pond snail was estimated to be > 100 mg/L and the 96-hour NOEC to be 100 mg/L, under the conditions of the test.
A study was performed to evaluate the inhibitory effect of IR5878 on the growth of the freshwater green algal speciesScenedesmus subspicatus. Groups of 3 parallel exponentially growing cultures were treated at the concentrations of 4.6, 10, 21, 46 and 100 mg/L and incubated in a water bath.EC50(biomass) was 41.4 mg/L. EC50(growth rate) was 87.1 mg/L. NOEC (72-h) for biomass and growth rate was 10 mg/L. LOEC (72-h) for biomass and growth rate was 21 mg/L.
A study was performed to evaluate the inhibitory effect of IR5878 on the growth of the freshwater blue algal speciesAnabaena flos-aquae. Groups of 3 parallel exponentially growing cultures were treated at the concentrations of 0.46, 1.0, 2.1, 4.6, 10 and 21 mg/L and incubated in a water bath. EC50(biomass) was 1.9 mg/L. EC50(growth rate) was 13.0 mg/L. NOEC (72-h) for biomass was mg/L. NOEC (72-h) for growth rate wasmg/L. LOEC (72-h) for biomass wasmg/L. LOEC (72-h) for growth rate was 0.79 mg/L.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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