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Diss Factsheets
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EC number: 280-489-7 | CAS number: 83567-04-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Principles of method if other than guideline:
- A study was conducted to determine the short term toxicity of the test substance to fish according to an unspecified method. Oryzias latipes were exposed for 96 h to the test substance at concentrations of 100, 500 and 1000 mg/L (nominal). Mortality was assessed daily.
- GLP compliance:
- no
- Specific details on test material used for the study:
- Batch no.: 40406
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Details on test solutions:
- Not recorded
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- - Name: Orange red killifish
- Length and weight: mean body length +/- SD = 23.9 +/- 1.44 mm, mean body weight +/- SD = 0.24 +/- 0.04 g - Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- No
- Hardness:
- Not recorded
- Test temperature:
- 25 +/- 1°C
- pH:
- Not recorded
- Dissolved oxygen:
- Not recorded
- Nominal and measured concentrations:
- 100, 500 and 1000 mg/L (nominal)
- Details on test conditions:
- 10 fish per condition
Test aquarium: Glass made (200 x 265 x 300 mm)
Test volume: 5 L per exposure concentration
Statistics: Probit method (p=0.05) - Reference substance (positive control):
- yes
- Remarks:
- Pentachlorophenol sodium salt
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- >= 100 - <= 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Results with reference substance (positive control):
- 96 h LC50 = 0.37 (0.32 - 0.42) mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Under the study conditions, the 96 h LC50 of the substance to Oryzias latipes was determined to be greater than 100 mg/L (nominal).
- Executive summary:
A study was conducted to determine the short term toxicity of the substance to fish according to an unspecified method. Oryzias latipes were exposed for 96 h to the test substance at concentrations of 100, 500 and 1000 mg/L (nominal). Mortality was assessed daily. Under the study conditions, the 96 h LC50 of the substance to Oryzias latipes was determined to be greater than 100 mg/L (nominal) (Yamada, 1984). The study is considered unsuitable for risk assessment purposes due to lack of information on the impurities of the test substance and on critical experimental data.
Reference
Description of key information
Under the read-across study conditions, the mean measured 96 h LC0 of the substance in Danio rerio was determined to be greater than 78 mg/L (measured) of the organic components (equivalent to 95 mg/L of the test substance including the inorganic components). The LC50 could not be determined due to absence of any adverse effects.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
A study was conducted to determine the short-term toxicity of the read-across substance to Zebra fish according to EU Method C.1, in compliance with GLP. The fish were exposed for 96 h to the test substance at concentrations of 0 and 100 mg/L. Mortality and symptoms (swimming action) were assessed daily. Analytical verification of test concentrations was conducted by TOC determination. There were no mortality or symptoms observed in any group. Under the study conditions, the mean measured 96 h LC0 of the substance in anio rerio was determined to be greater than 78 mg/L of the organic components (equivalent to 95 mg/L of the test substance including inorganic components) (Caspers, 1999). The LC50 could not be determined due to absence of any adverse effects.
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