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EC number: 280-489-7 | CAS number: 83567-04-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From July 01, 1982 to July 15, 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- The acute oral toxicity of the substance was conducted in male and female ICR mice through oral gavage of a single dose at concentrations of 0, 2500 and 5000 mg/kg bw. The mortality, clinical signs and body weights were examined for 2 weeks thereafter. Thereafter, all surviving animals were necropsied for gross pathological examination of main tissues and organs.
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Trisodium 7-[[4-chloro-6-[ethyl[3-[[2-(sulphonatooxy)ethyl]sulphonyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3-[(4-methoxy-2-sulphonatophenyl)azo]naphthalene-2-sulphonate
- EC Number:
- 280-489-7
- EC Name:
- Trisodium 7-[[4-chloro-6-[ethyl[3-[[2-(sulphonatooxy)ethyl]sulphonyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3-[(4-methoxy-2-sulphonatophenyl)azo]naphthalene-2-sulphonate
- Cas Number:
- 83567-04-8
- Molecular formula:
- C30H28ClN7O14S4.3Na C30H25ClN7Na3O14S4
- IUPAC Name:
- trisodium 7-[[4-chloro-6-[ethyl[3-[[2-(sulphonatooxy)ethyl]sulphonyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3-[(4-methoxy-2-sulphonatophenyl)azo]naphthalene-2-sulphonate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Origin: Charles River Japan Inc.
Acclimatization: at least 7 d
Body weight at start for males: 26 - 31 g and for females: 21 - 25 g
Age: ca. 5 weeks
Temperature and relative humidity: 23 +/- 1°C and 60 +/- 10%, respectively
Food: CE-2 type, ad libitum (withdrawal from about 20 h before to 3-4 h after treatment)
Water: tap water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The test substance appropriately diluted with distilled water was orally administered into the stomach by using a glass syringe attached gastric probe to groups of 10 animals of each sex at rate of 10 or 20 mL per kg bw.
- Doses:
- 0 (negative control), 2500 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- The clinical signs and the mortality were observed at 1/6, 1/2, 1, 2 and 4 hours after administration and daily (at 10 a.m.) for 2 weeks thereafter (observation period). Body weight of each animal was measured at Days 0, 7 and 14. All animals which were alive at the end of the observation period were necropsied for gross pathological examination of main tissues and organs.
- Statistics:
- - Comparison with the negative controls
T-test for the body weight analysis
Fisher exact test for incidence of gross finding
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed in the study.
- Clinical signs:
- No treatment-related clinical signs were observed at any of the tested doses.
- Body weight:
- There was no test substance-related body weight change.
- Gross pathology:
- Some abnormal findings such as accentuated lobular pattern in the liver, vesicle or fade area in the kidney, white substance present or retension of urine in the urinary bladder, uterine horn distended with fluid and fluid filled cyst surrounded in the ovary were found in some animals including controls. However, no remarkable test substance-related macroscopic modifications in main tissues and organs were found in any treated animal.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the study conditions, the acute oral LD50 of the substance in mice was determined to be greater than 5000 mg/kg bw.
- Executive summary:
A study was conducted to determine the acute oral toxicity of the substance according to an internal method of the laboratory, in compliance with GLP. Male and female ICR mice were administered by oral gavage a single dose of the test substance at 0, 2500 and 5000 mg/kg bw. Rats were fasted 20 h pre-test to 3 -4 h post-application. The clinical signs and mortality were observed at 10 min, 30 min, 1, 2 and 4 h after administration and daily for 2 weeks thereafter. Body weight of each animal was measured at Days 0, 7 and 14. Thereafter, the surviving animals were necropsied for gross pathological examination of main tissues and organs. No mortality and clinical sign were observed during the study. Also, there were no test substance-related body weight changes or macroscopic modifications. Under the study conditions, the acute oral LD50 of the substance in mice was determined to be greater than 5000 mg/kg bw (Hosokawa, 1982).
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