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Diss Factsheets
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EC number: 201-933-8 | CAS number: 89-72-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The substance is a monoconstituent with >98-100% (w/w) purity. The substance was evaluated according to latest Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7c: Endpoint specific guidance; Version 2.0 November 2014).
The substance is liquid with a molecular weight between 150.2196g/mol, moderate water solubility of 1.46 g/L and log Pow = 3 at ambient conditions. The vapour pressure is low, i.e. 2.98 Pa = 2.24 x 10E-2mm Hg. Assessment of the molecular, physicochemical and toxicological properties leads to following conclusions:
- Oral/GI absorption:
Based upon the molecular structure and weight, moderate water solubility and high log Pow, and toxicological signs after oral dosing, oral absorption is most likely. From a conservative viewpoint, 100% oral absorption is considered.
- Respiratory absorption:
Based upon the low vapor pressure, evaporation and inhalation of the substance is unlikely. Deposition in the airways is therefore assumed to be absent and absorption by inhalation is considered to be negligible. From a conservative viewpoint, 30% inhalation absorption is considered.
- Dermal absorption:
Most of the physicochemical and toxicological parameters are in favour of dermal absorption. Dermal absorption is considered to be likely and comparable to oral absorption (100%). This is supported by an estimated dermally absorbed dose (DAD) of 6.2 mg/kg bw/day by means of Episuite Dermwin, which is considered substantial compared to DNELs.
For the assessment of distribution, metabolism and excretion physicochemical and toxicological properties are also taken into account, and following conclusions were deduced:
- Distribution:
Based upon the low molecular weight, high Log P and moderate water solubility, as well as target organs (liver and CNS), distribution is very likely.
- Metabolism & accumulation potential
For the various tissues mentioned, there is no direct indication of bioaccumulation potential.
- Excretion:
Excretion via the urine, breast milk and saliva/sweat are likely because of the ionisable structure, small molecular weight and moderate water solubility. Excretion via the air, bile, hair/nails and exfoliation are less likely.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 30
Additional information
More detailed information is given in the Basic Toxicokinetics assessment attached.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.