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Diss Factsheets
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EC number: 219-553-6 | CAS number: 2461-15-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50(oral, rat, 24h): >5000 mg/kg bw;
LD0(dermal, rabbit, 72h): >4000mg/kg bw
LC50(inhalation, rat, 7h): >0.15 mg/L
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC0
- Value:
- > 0.15 mg/L air
- Physical form:
- inhalation: mixture of gas and vapour
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 4 000 mg/kg bw
Additional information
An acute toxicity study (Dr. med. vet. W v Kobel, 1983) for the target substance was conducted by oral application following OECD guideline 401. Upon oral administration and a 14 day post-treatment observation period, the LD50 determined for test substance is greater than 5000 mg/kg bw. Twenty animals were administered at concentrations of 5’000 and 1’000 mg/kg bw. Dyspnoea, exophthalmus, ruffled fur and curved body position were seen, being common symptoms in acute test. In addition, the high dose animals showed sedation, tremor and ventral body position. However, lack of any clear dose-relation or adverse effects on body weight, gross pathological appearance indicated an absence of toxicity. Thus, it can be concluded that test substance exerts no toxic influence in rats of either sex at levels up to 5’000 mg/kg bw.
As the test material is a liquid with high boiling point (233 ±1 °C) and low vapour pressure (29 Pa at 25 °C), it is reasonable to expect that the inhalation route will not be an significant exposure route to the test material. An acute toxicity study by inhalation performed with a suitable surrogate substance dosed up to saturation concentration, exposing rats for 7 hours is available, confirming absence of acute toxicity by inhalation (LC0 > 0.15 mg/L) that can be used as read-across information to the target substance, as outlined.
For assessing acute toxicity via the dermal route a study for C12 -14 alkyl glycidyl ether exposed to rabbits is available, showing absence of mortality up to 4.5 ml/kg bw (equivalent to LD0 of ~4’000 mg/kg bw) which was the highest dose tested in this study. No mortality was seen in any of the dose groups tested.
Thus, it is justifiable to use these data for read across to 2-ethylhexyl glycidyl ether ,avoiding duplicate tests due to limited available information of target substance.
Justification for classification or non-classification
Based on the experimental results from oral, inhalation and dermal pathway, test substance is not to be classified according to CLP (Regulation EC No. 1272/2008) for acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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