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Diss Factsheets
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EC number: 201-152-2 | CAS number: 78-87-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- publication
- Title:
- OECD SIDS 1,2-DICHLOROPROPANE
- Author:
- OECD SIDS
- Year:
- 2 003
- Bibliographic source:
- UNEP PUBLICATIONS
- Report date:
- 2003
Materials and methods
- Objective of study:
- distribution
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA test rule study
- Principles of method if other than guideline:
- EPA test rule study.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,2-dichloropropane
- EC Number:
- 201-152-2
- EC Name:
- 1,2-dichloropropane
- Cas Number:
- 78-87-5
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,2-dichloropropane
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- other: air
- Duration and frequency of treatment / exposure:
- 6 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Doses, males: 5, 50 or 100 ppm
Doses, females: 5, 50 or 100 ppm
- No. of animals per sex per dose / concentration:
- 4 males and 4 females
- Control animals:
- not specified
Results and discussion
Metabolite characterisation studies
- Details on metabolites:
- Approx. 60-90% of the radioactivity present in the exhaled volatile fraction was unchanged PDC. HPLC analysis of urine (pooled from the 3 inhalation experiments) revealed the presence of three n-acetylcysteine conjugates of PDC (N-acetyl-S-(2-hydroxypropyl)-L-cysteine, N-acetyl-S-(2-oxopropyl)-L-cysteine and N-acetyl-S-(2-carboxyethyl)-L-cysteine) but no detectable parent compound. Attempts to identify four other HPLC peaks were unsuccessful.
Any other information on results incl. tables
The measured concentration of PDC in the chambers was 4.6/4.7 ppm, 52.4/56.8 ppm and 141.8/125.2 ppm for males/females, respectively, in the low, mid and high exposure groups, respectively. Mean end exposure body burdens were 0.4/0.3, 2.8/2.8 and 6.3/7.1 mg equivalents of PDC for males/females in the low, mid and high exposure groups, respectively. The distribution of recovered radioactivity is summarized in Attachment 5.0b. In summary, urine (54-66% of recovered dose) and expired air (15-23% as carbon dioxide) were the principle routes of excretion with smaller amounts present in tissues and carcass (6-10%) and faeces (6-10%). Less than 4% of the recovered radioactivity was present in cage washings. Exhaled volatiles accounted for 2-3% of the dose in animals exposed to 5 ppm and 50 ppm, and 6-7% in the 100 ppm group (high dose group significantly different from mid and low dose groups). The pattern of excretion did not differ between males and females.
Analysis of tissues
Radioactivity was distributed among all the tissues examined and generally represented less than 0.18% of the recovered dose/g wet weight. The liver and kidneys contained the highest amount of radioactivity, accounting for 0.1-0.3% and 0.1-0.2% of the dose/g wet weight, respectively. There were no obvious differences in tissue distribution between the sexes or in distribution or concentration for the different exposure concentrations.
Timecourse for elimination
Urinary elimination of radiolabel was greatest over the first 24 hr post-dosing (47-62% of dose) relative to the following 24 hr (2-9%). Comparative figures for exhaled carbon dioxide were 13-20% and <3%, and 5-8% and 0.7-3.0% for faeces (at 0-24 and 24-48 hr, respectively). The majority of exhaled volatiles were also eliminated during the 24 hr following exposure, with <0.03% detected during the 24-48 hr time period.
Blood concentrations in both sexes were generally at a maximum 4 hr into the exposure (exception: 5 ppm females which peaked at 1 hr). In both sexes the peak blood PDC level was not proportional to dose indicating a dose-dependent non-linearlity in clearance. The concentration in blood was below the limit of detection (0.03 ug/g) 2 hr after exposure ended. Modelling (one-compartment open model with linear fit) indicated a post-exposure blood clearance half life for PDC of 30 min in males and 24 min in females.
In plasma, the highest concentration of 14C in both sexes was found at 4 hr in the exposure, and ranged from 2, 12-15 and 27-29 ug eq/g plasma present in the 5, 50 and 100 ppm groups respectively. Corresponding AUCs were 21-23, 130-134 and 288-320 ug g^-1, respectively. Comparison of the 5 ppm peak plasma 14C level and AUC with the mid- and high dose groups indicated that plasma 14C was less than proportional to dose.
Applicant's summary and conclusion
- Conclusions:
- Urine and exhaled carbon dioxide were the principle routes for elimination of PDC in male and female rats after 6 hr inhalation exposure to 5, 50 or 100 ppm. The majority of radioactivity was excreted within 24 hr, with little unchanged PDC present.
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