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Diss Factsheets
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EC number: 222-733-7 | CAS number: 3590-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- nda
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: GLP compliance is not noted. Method of experimentation is not a standard guidance. Method follows Krebs (1983).
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Untersuchungen zur aquatischen toxizitat zinnorganischer verbindungen (Investigations on the Aquatic Toxicity of Organotin Compounds)
- Author:
- Steinhaeuser, K.G., W. Amann, A. Spaeth, and A. Polenz.
- Year:
- 1 985
- Bibliographic source:
- Vom Wasser. 65:203-214.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No other information provided.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- tetraoctytin
- IUPAC Name:
- tetraoctytin
- Details on test material:
- Tetraoctyltin; no other information given
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No information.
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Saturated solutions
- Sampling method: Sample solutions prepared in distilled water via vigorous shaking
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Saturated solutions created via vigorous shaking
- Eluate: None
- Differential loading: Not given
- Controls: Not described
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): No vehicle
- Concentration of vehicle in test medium (stock solution and final test solution(s) including control(s)): N/A
- Evidence of undissolved material (e.g. precipitate, surface film, etc): None given
Test organisms
- Test organisms (species):
- Photobacterium phosphoreum
- Details on inoculum:
- No information.
Study design
- Test type:
- not specified
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 30 min
- Post exposure observation period:
- Unclear, not stated
Test conditions
- Hardness:
- Not given
- Test temperature:
- Not given
- pH:
- Not given
- Dissolved oxygen:
- Not given
- Salinity:
- Not given
- Nominal and measured concentrations:
- Only 30 min EC50 value given
- Details on test conditions:
- None given
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrations
- Duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- 0.63 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: inhibition of bioluminescence
- Details on results:
- None given
- Results with reference substance (positive control):
- None given
- Reported statistics and error estimates:
- No details available on statistics
Any other information on results incl. tables
No information.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The EC50 for P. phosphreum is 0.63 µg/L by inhibition of phosphoresence.
- Executive summary:
Owing to the low solubility, the active concentration is less than 1 mg/L for almost all organotin compounds having a demonstrated toxic effect on the test organisms. Basically, however, it should be noted that the determined saturation concentrations are only slightly higher than the toxic active concentrations in cetain cases.
The selected toxicity data from the literature, are often in good agreement with the test results achieved here, as regards the order of magnitude. However, certain publications have also published toxic active concentrations which are far beyond the solubility limits. Presumably, the accompanying analysis necessary for poorly soluble compounds was not performed in these studies; therefore it is to be assumed that a large portion of the test substance was present in undissolved or adsorbed and, thus, biologically unavailable form.
The following trends are clear from the results achieved thus far:
Due to their low solubility, the tetraorganotin compounds are to be evaluated less critically than the triorganotin compounds, despite their low EC values. It cannot be ruled out that the toxicity here is significantly influenced by more easily soluble trace impurities of triorganotin compounds, which accumulate in the aqueous phase. Thus, for tetrabutyltin, it can be observed that an increase in the measured amount from 50 mg/L to 1000 mg/L when preparing the aqueous solution increases the toxicity to luminescent bacteria (Photobacterium phosphoreum) by a factor of 22. Furthermore, in an aqueous solution of tetraphenyltin (measured amount 15 mg/L), one can detect 3.1 µg/L of triphenyltin, besides 30 µg/L of tetraphenyltin.
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