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EC number: 243-001-3 | CAS number: 19372-44-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 18-21, 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to OECD guideline and GLP. No CoA included in the report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- 72 hour observation period instead of 14 days
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Bis(pentane-2,4-dionato)calcium
- EC Number:
- 243-001-3
- EC Name:
- Bis(pentane-2,4-dionato)calcium
- Cas Number:
- 19372-44-2
- Molecular formula:
- C10H14CaO4
- IUPAC Name:
- calcium bis[(2Z)-4-oxopent-2-en-2-olate]
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Name: Ca-Acetylacetonate
Batch No.: 106002
Physical state: Powder
Purity: 98%
No CoA included in the report.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harald Schriever, Kaninchenfann, D-2740 Bremervorde, Neuendamm 88
- Age at study initiation: no data
- Weight at study initiation: no data
- Housing: individual housing (50 x 45 x 40 em, L x B x H) in a battery of cages, each equipped with a paper roll disposal system.
- Diet (e.g. ad libitum): ad libitum, Ssniff K pellets
- Water (e.g. ad libitum): ad libitum, drinking water as for human consumption
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20±3
- Humidity (%): 30-70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light):12/12
IN-LIFE DATES: November18-21,1991.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Remarks:
- The test article was moistened sufficiently with aqua ad iniectabilia.
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 30-6 0min, 24, 48 and 72h after patch removal.
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: back
- % coverage: 6cm2
- Type of wrap if used: Each test area was covered with a semi-occlusive dressing consisting of KosmoplastR (Medilog), which was held in place by non-irritating tape ElastoplastR (BeiersdorfAG, Hamburg), and StiiIpaR (p.HartmannAG, Heidenheim/Brenz), which enveloped the whole of the animal's trunk.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the dressing was removed and any residual sample was carefully washed off with water or an appropriate solvent.
- Time after start of exposure: At the end of the 4-hexposure period.
SCORING SYSTEM:
Erythema and Eschar Formation
0 No erythema
1 Very slight erythema (barely perceptible)
2 Well-defined erythema
3 Moderate to severe erythema
4 Severe erythema (beetredness) to slight eschar formation (injuriesindepth)
Maximum possible = 4
Oedema Formation
0 No oedema
1 Very slight oedema (barely perceptible)
2 Slight oedema (edges of area well defined by definite raising)
3 Moderate oedema (raised approximately 1mm)
4 Severe oedema (raised more than 1mm and extending beyond area of exposure)
Maximumpossible = 4
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 30-60 min, 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No effects on skin were observed in this study
- Irritant / corrosive response data:
- No test article-dependent findings were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No test article-dependent findings were observed. The test substance is not irritating to skin.
- Executive summary:
The potential toxicity of "Ca-Acetylacetonate" was assessed in an acute dermal irritation/corrosion test on 6 albino rabbits. The skin was exposed to the test substance for 4 h. Animals were examined for signs of erythema and oedema at 30-60 min, 24, 48 and 72 h post-exposure. No test article-dependent findings were observed. The test substance is not irritating to skin.
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