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EC number: 500-039-8 | CAS number: 25322-69-4 1 - 4.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data to permit interpretation of study results
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tetrapropylene Glycol Crude
- IUPAC Name:
- Tetrapropylene Glycol Crude
- Details on test material:
- Name of test material (as cited in study report): Tetrapropylene Glycol Crude.
Molecular Formula: C12H26O5.
Molecular Weight: 250+.
Physical state: Black liquid.
Synonyms: Tripropylene Glycol Bottoms.
Reference: TB 840322-1216 A&B.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
Age at study initiation: 6-8 week old Sprague Dawley Rats.
Weight at study initiation: 280 - 427 g.
Fasting period before study: Overnight.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- 1-hour exposure of 4 male rats to vapour of the test material generated at room temperature (calculated to contain 0.17 mg/L based on weight of sample before and after exposure).
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 0.17 mg/L
- No. of animals per sex per dose:
- 4 animals at the dose level of 0.17 mg/L
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 14 days.
Frequency of observations and weighing: The animals were weighed before dosing, the day after dosing, and at 1 and 2 weeks after dosing. The animals were observed closely the day of treatment, then periodically for the 2-week observation period.
Necropsy of survivors performed: yes.
Other examinations performed: clinical signs, body weight. - Statistics:
- none
Results and discussion
- Preliminary study:
- n/a
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 0.17 mg/L air
- Based on:
- test mat.
- Mortality:
- There was no mortality during the study.
- Clinical signs:
- other: There was no mortality during the study.
- Body weight:
- All rats gained body weight during the 2-week observation period.
- Gross pathology:
- No lesions attributable to administration of the test material were observed upon gross pathological examination 2 weeks post treatment.
- Other findings:
- none
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Interpretation of results:
- other: The test was conducted on a very low concentration which is 0.17 mg/L, so Tetrapropylene Glycol Crude could not be classified for the inhalation end point based on this study report.
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Under the testing conditions of this study, the acute inhalation LC50 of Tetrapropylene Glycol Crude is greater than 0.17 mg/L in Sprague Dawley
rats. - Executive summary:
The test material, Tetrapropylene Glycol Crude, also known as Tripropylene Glycol Bottoms, was submitted for acute inhalation toxicological evaluation.
A 1-hour exposure of 4 male rats to vapour of the test material generated at room temperature (calculated to contain 0.17 mg/L based on weight of sample before and after exposure) resulted in no apparent adverse effects. There was no mortality during the study.
All rats appeared healthy and gained body weight during the 2-week observation period.
No lesions attributable to administration of the test material were observed upon gross pathological examination 2 weeks post treatment.
Under the testing conditions of this study, the acute inhalation LC50 of Tetrapropylene Glycol Crude is greater than 0.17 mg/L in Sprague Dawley rats.
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