Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-817-4 | CAS number: 74-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic toxicity data on fish, algae and plants are available for chloromethane but as chloromethane is a volatile substance, closed systems are required to maintain stable test concentrations. Alternatively, exposure concentrations can be verified using analytical measurements. It is unclear from the description of the studies if vessels were closed or not, and because all results are based on nominal concentrations the results should be evaluated with caution, except for the Daphnia magna study from DOW (2002). The Daphnia magna study was conducted under static-renewal test conditions (renewel at 24h) in a closed (no headspace) system and analysis of exposure solutions following 24 hours of aging in closed vessels without headspace showed little to no loss of test substance.
Chloromethane can be considered as a chemical which acts by narcotic toxicity, based on the classification system developed and validated by Verhaar et al. (1992; 2000). It is a chemical containing carbon, hydrogen and a halogen. This implies that the effects in the aquatic environment of chloromethane can be well described by QSARs for so-called Narcosis Class I type compounds (Verhaar et al, 1992). This QSAR uses the octanol-water partitioning constant Kow as a descriptor to assess the toxicity. For chloromethane, calculated log Kow values of 0.9-1.09 have been published (Eurochlor, 2006). Calculations were carried out using log Kow of 0.91 for chloromethane giving the highest estimated toxicity (SIDS, 2002).All data - experimental as well as QSAR estimates - give comparable results for fish, daphnia and aquatic plants. They indicate a relatively low toxicity. Therefore, it is justified to derive a PNEC based on the most sensitive short term study withDaphnia magna, revealing the most sensitive reliable result using an assessment factor of 1000:
LC50 (48h) = 200 mg/L Daphnia magna.
The amount of chloromethane introduced into the environment must be seen in the context of the background input due to natural sources and the available data on aquatic organisms show toxicities of chloromethane far in excess of natural occurring concentrations. Backround concentrations of chloromethane is available, most of them in the. One European study was found (Hendriks & Stouten, 1993), a maximum concentration of 12μg/L in the riverwas reported (CIDCAD 28, 2000).Actual monitoring data (2010) from different productions sites inreveal concentrations of 3 µg/L and < 10 µg/L in the effluents of sewage treatment plants.Two ranges of (marine) aquatic exposure concentrations are given in the literature. These are in good agreement. The ranges are 3 to 5 ng/L for ocean water samples (Moore et al., 1996) and concentrations in sea water reported by Harper (2000) were 5 ng/L, with a range of 4-6 ng/L (EuroChlor, 2006).
Furthermore, as high production volume substances chloromethane have been reviewed to a great extant for their exposure potential to the environment and the possible risks arising from the substance (BUA 1986, OECD SIDS 2002, CICAD 2000 and Euro Chlor 2006,Environment Canada, 2009). It was concluded that chloromethane is currently of low priority for further work because of its low hazard profile.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.