Registration Dossier
Registration Dossier
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EC number: 807-461-4 | CAS number: 1489170-67-3
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP study, but test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- The objective of this study was to determine the solubility of the test substance in water by HPLC.
- GLP compliance:
- no
- Type of method:
- other: HPLC
Test material
- Reference substance name:
- sodium 4-[(4-chlorobenzoyl)amino]benzoate
- EC Number:
- 807-461-4
- Cas Number:
- 1489170-67-3
- Molecular formula:
- C14H9ClNNaO3
- IUPAC Name:
- sodium 4-[(4-chlorobenzoyl)amino]benzoate
- Test material form:
- not specified
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 6.86 g/L
- Temp.:
- 25 °C
- pH:
- 11.1
- Remarks on result:
- other: average of 4 determinations
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The water solubility of the test material has been determined to be 6.86 g/L (at 25°C and pH 11.1) using HPLC. Previous solubility tests were carried out in DI water with a pH of 7, which generated a small amount of insoluble free acid, visual inspection of the dissolution was therefore difficult. Ensuring alkalinity of the aqueous system keeps the equilibrium on the salt side of the equation, and more accurate solubility determinations can be made. The study was performed in accordance with generally accepted scientific standards and described in sufficient detail and therefore reliability of Klimisch 2 has been assigned.
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