Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 201-476-4 | CAS number: 83-43-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Methylprednisolone, Summary Report
- Author:
- The European Agency for the Evaluation of Medicinal Products, Committee for Veterinary Medicinal Products
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
- Limit test:
- no
Test material
- Reference substance name:
- 86401-95-8
- Cas Number:
- 86401-95-8
- IUPAC Name:
- 86401-95-8
- Reference substance name:
- Methylprednisolone aceponate
- IUPAC Name:
- Methylprednisolone aceponate
- Reference substance name:
- 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione, 21-acetate 17-propionate
- IUPAC Name:
- 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione, 21-acetate 17-propionate
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- subcutaneous
- Doses:
- 0-3000 mg/kg bw
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Conclusions:
- When the test substance was administered to rats subcutaneously, the LD50 value was greater than 3000 mg/kg bw, the highest dose administered.
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