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Diss Factsheets
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EC number: 443-090-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From February 19, 2002 to February 21, 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling schedule for chemical analysis: at 0 and 48 h
- Vehicle:
- no
- Details on test solutions:
- Test solution: To produce the only test concentration, 105.3 mg of the test substance was added to 1 L of dilution water and treated with a magnetic stirrer.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Straus
- Sex: parthenogenetic females
- Source: strain of Bundesgesundheitsamt Berlin
- Age at study initiation: neonates
- Food type: green algae (Desmodesmus subspicatus)
- Frequency:ad libitum
ACCLIMATION
A population of parthenogenetic females of synchronized age structure which had been maintained for more than 15 years in the test facility under constant temperature conditions (20±1°C) at a 16:8 h light-dark photoperiod (illumination: < 1000 lux) were used in the study. The culture water (so-called 'M4 medium') was partly renewed once a week. The Daphnia were exclusively fed with unicellular green algae (Desmodesmus subspicatus) 'ad libitum'. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 271.3 mg CaCO3/L
- Test temperature:
- 18-22°C
- pH:
- 7.7
- Dissolved oxygen:
- Control: 8.5 mg/L
Test: 8.6 mg/L - Nominal and measured concentrations:
- Nominal concentration: 100 mg/L
Measured concentration: measurement was carried out in terms of TOC
0 h = 106% of nominal (= 70 mg/L of organic components of the test substance)
48 h = 106% of nominal (= 70 mg/L of organic components of the test substance)
The analytical values indicate a good recovery rate. - Details on test conditions:
- TEST SYSTEM
- Test vessel: 50 mL glass beakers holding 10 neonates in 20 mL of test medium
- Type: closed bottle
- Aeration: none
- Type of system: static
- No. of organisms per vessel: 10 neonates per vessel
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Biomass loading rate: 2 mL per neonate
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water ('M4 medium'), originally described in Water Research 24 (9): 1157-1167), prepared according to the recommendations of Bundesgesundheitsamt Berlin
- Total organic carbon: <2 mg/L
- Timepoint of water quality measurement: 48 h
OTHER TEST CONDITIONS
- Photoperiod: 16 h light : 8 h dark
- Test concentrations: 100 mg/L (nominal) - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 106 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 106 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Immobilization in control: 0
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the test conditions, the 48 h EC50 and NOEC of the test substance were found to be ≥100 mg/L.
- Executive summary:
A limit test was conducted to determine the acute toxicity of the test substance to Daphnia magna according to EU Method C.2 (equivalent or similar to OECD Guideline 202), in compliance with GLP.
In this test, 2 replicates of 10 Daphnia magna neonates were exposed to a nominal concentration of 100 mg/L under static conditions for 48 h. Immobility was recorded at 24 and 48 h. Measured concentrations were equivalent to ca. 106% of nominal values at both 0 and 48 h.
Under the test conditions, the 48 h EC50 and NOEC of the test substance were ≥100 mg/L (nominal concentration).
Reference
Time [h] |
EC 50 [mg/L] (test substance) |
24 |
≥100 |
48 |
≥106 |
The results are expressed in terms of nominal concentrations (at 24 h), and in terms of mean measured concentrations (at 48 h). Measured concentrations ranged from 106 (at 0 h) to 106% (at 48 h) of nominal value.
Description of key information
Under the test conditions, the 48 h EC50 and NOEC of the test substance were found to be ≥100 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 100 mg/L
Additional information
A limit test was conducted to determine the acute toxicity of the test substance to Daphnia magna according to EU Method C.2 (equivalent or similar to OECD Guideline 202), in compliance with GLP. In this test, 2 replicatesof 10 Daphnia magna neonates were exposed to a nominal concentration of 100 mg/L under static conditions for 48 h.Immobility was recorded at 24 and 48 h. Measured concentrations were equivalent to ca. 106% of nominal values at both 0 and 48 h. Under the test conditions, the 48 h EC50 and NOEC of the test substance were ≥100 mg/L (nominal concentration).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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