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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
Safety Assessment of Xylene Sulfonic Acid, Toluene Sulfonic Acid, and Alkyl Aryl Sulfonate Hydrotropes as Used in Cosmetics
Author:
Wilma F. Bergfeld, Donald V.Belsito, Curtis D. Klaassen, RonaldHill, Daniel Liebler, James G.Marks, Jr, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen
Year:
2011
Bibliographic source:
International Journal of Toxicology; Vol 30, Issue 6_suppl, pp. 270S - 283S; 2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
To assess the ocular irritation potential of Sodium cumenesulphonate in rabbits according to OECD 405 Guidelines
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium cumenesulphonate
EC Number:
248-983-7
EC Name:
Sodium cumenesulphonate
Cas Number:
28348-53-0
Molecular formula:
C9H12O3S.Na
IUPAC Name:
sodium 2-phenylpropane-2-sulfonate
Test material form:
solid
Details on test material:
Name of the test chemical: Sodium cumenesulphonate
Molecular Weight: 223.2468 g/mol
Molecular Formula:C9H12O3S.Na
Substance Type: Organic
SMILES Notation :c1(ccccc1)S(=O)(=O)[O-].[Na+].CC([*])C
Physical State: Solid
Specific details on test material used for the study:
Name of the test chemical: Sodium cumenesulphonate
Molecular Weight: 223.2468 g/mol
Molecular Formula:C9H12O3S.Na
Substance Type: Organic
SMILES Notation :c1(ccccc1)S(=O)(=O)[O-].[Na+].CC([*])C
Physical State: Solid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
no data available
Duration of treatment / exposure:
no data available
Observation period (in vivo):
no data available
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
no data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
no irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Sodium cumenesulphonate was not irritating to rabbit eyes
Executive summary:

An ocular irritation study in rabbits was performed to assess the irritation potential of Sodium cumenesulphonate. The test was performed in accordance with OECD 405 Guidelines.

Undiluted Sodium cumenesulphonate instilled in to the rabbit eyes and effects were observed (dose and duration not specified)

Sodium cumenesulphonatewas not irritating to rabbit eyes.