Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate

Hydrolysis

Administrative data

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2003-02-06 to 2003-02-13

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2003

Report date:

2013

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)

Version / remarks:

EG-guideline 92/69

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate

EC Number:

249-616-3

EC Name:

Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate

Cas Number:

29420-49-3

Molecular formula:

C4HF9O3S.K

IUPAC Name:

potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

Specific details on test material used for the study:

Source and lot/batch No.of test material: K100
- Expiration date of the lot/batch: August 12, 2004
- Purity: 98.7%
- Purity test date:August 12, 2002

Radiolabelling:

no

Study design

Analytical monitoring:

yes

Details on sampling:

- Sampling intervals for the parent/transformation products: Day 0 and day 5.

Buffers:

- Composition of buffer:
pH 4:: citric acid / potassium hydroxide / sodium chloride;
pH 7: potassium dihydrogen phosphate / Di-sodium hydrogen phosphate;
pH 9: borax / hydrochloric acid;

Duration of test

Duration of test 1

Duration:

5 d

pH:

4

Temp.:

50 °C

Initial conc. measured:

98.3 other: %

Duration of test 2

Duration:

5 d

pH:

7

Temp.:

50 °C

Initial conc. measured:

98.2 other: %

Duration of test 3

Duration:

5 d

pH:

9

Temp.:

50 °C

Initial conc. measured:

98.1 other: %

Positive controls:

not specified

Negative controls:

not specified

Results and discussion

Transformation products:

not measured

Dissipation DT50 of parent compound

Dissipation DT50 of parent compound 1

Key result

pH:

7

Temp.:

25 °C

DT50:

> 1 yr

Type:

(pseudo-)first order (= half-life)

Dissipation DT50 of parent compound 2

Key result

pH:

4

Temp.:

25 °C

DT50:

> 1 yr

Type:

(pseudo-)first order (= half-life)

Dissipation DT50 of parent compound 3

Key result

pH:

9

Temp.:

25 °C

DT50:

> 1 yr

Type:

(pseudo-)first order (= half-life)

Details on results:

A Tier 1 hydrolysis of PFBSK+ was determined. No changes in the concentration were observed after 5 days at 50 °C and at pH 4, 7 , and 9. The % degradation at pH 4, pH 7 and pH 9 was less than 10% after 5 days at 50 °C. As defined in the tst guideline, since less than 10% of hydrolysis occurs after a period of 5 days at 50°C at pH levels of 4, 7 and 9, the test substance is considered hydrolytically stable (t1/2 at 25 °C > 1 year) and no further testing is required.

Any other information on results incl. tables

Table 1: Hydrolysis data for study A02/0124/05 LEV

pH	Initial Conc. (%)	Day 5 Conc. (%)	% Hydrolysis at 50 °C
4	98.3	98.2	< 10%
7	98.2	98.2	<10%
9	98.1	98.1	< 10%

 

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

PFBSK+ has a hydrolysis half life of > 1 year under environmental conditions (25°C), it is considered hydrolytically stable.

Executive summary:

A Tier 1 hydrolysis of PFBSK+ was determined according to EU method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH).

 

Samples were prepared at a concentration of approximately 0.1 mole/L of PFBSK+ in each of pH 4, 7, and 9 buffer system and 50 °C. The concentration was analyzed with F-NMR at day 0 and after 5 days. No changes in the concentration were observed and the Hydrolysis was determined by % loss of the parent material. The % hydrolysis at pH 4, pH 7 and pH 9 were less than 10%. As defined in EU method C.7 , since less than 10% of hydrolysis occurs after a period of 5 days at 50°C at pH levels of 4, 7 and 9, the test substance is considered hydrolytically stable (t1/2 @25°C > 1 year) and no further testing is required.

 

This is a guideline study conducted under GLP. However, it lacks detailed documentation on the analytical information. Therefore, it is considered reliable with restrictions.