Naphthalene-2,6-dicarboxylic acid

Endpoint summary

Link to relevant study record(s)

Reference

Endpoint:

basic toxicokinetics, other

Type of information:

not specified

Adequacy of study:

other information

Reliability:

other: General Assessment

Principles of method if other than guideline:

Expert Assessment

GLP compliance:

no

Remarks:

No Experimental Results

Type:

absorption

Results:

Based on the observation of sytemic toxic effects on blood (higher reticulocytes and lower RBC values) in female rats in the 28-day Japanese study with a repro/developmental component, 2,6-NDA is systemically absorbed after oral dietary exposure

Type:

distribution

Results:

Based on the observation of sytemic toxic effects on blood (higher reticulocytes and lower RBC values) in female rats in the 28-day Japanese study with a repro/developmental component, 2,6-NDA is systemically distributed after oral dietary exposure

Conclusions:

After oral exposure, 2,6-naphthalene dicarboxylic acid is absorbed and systemically distributed. This has been experimentally confirmed, as systemic toxic effects at the highest dose of 2,6-naphthallene dicarboxylic acid in the Japanese 28-day study, that included repro and developmental compenents, were observed. Those effects included increased liver and reticulocyte counts and decreased red blood cells in parental generation females.

Further support for systemic absorbtion and distribution of 2,6-naphthalene dicarboxylic acid is provided by the physical and chemical properties of the molecule, which include a low molecular weight (216.19 daltons) and two carboxyl groups that increase solubility and are targets for conjugation.