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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 905-728-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation: aquatic / sediment
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Accepted model for calculation bioaccumulation results.
Data source
Referenceopen allclose all
- Reference Type:
- other: Model Results
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
- Reference Type:
- publication
- Title:
- European Uniion Risk Assessment Report: Phenol
- Author:
- ECB
- Year:
- 2 006
- Bibliographic source:
- ECB
- Report date:
- 2006
Materials and methods
- Principles of method if other than guideline:
- BCFBAF v3.0 model results.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethylhexyl diphenyl phosphite
- EC Number:
- 239-716-5
- EC Name:
- 2-ethylhexyl diphenyl phosphite
- Cas Number:
- 15647-08-2
- Molecular formula:
- C20H27O3P
- IUPAC Name:
- phosphorous acid, 2-ethylhexyl diphenyl ester
Constituent 1
Study design
- Route of exposure:
- other: model results
- Test type:
- other: model results
- Water / sediment media type:
- not specified
Results and discussion
Any other information on results incl. tables
BCFBAF Program (v3.00) Results:
==============================
SMILES : O(P(Oc(cccc1)c1)Oc(cccc2)c2)CC(CCCC)CC
CHEM : Phosphorous acid, 2-ethylhexyl diphenyl ester
MOL FOR: C20 H27 O3 P1
MOL WT : 346.41
--------------------------------- BCFBAF v3.00 --------------------------------
Summary Results:
Log BCF (regression-based estimate): 3.86 (BCF = 7.25e+003 L/kg wet-wt)
Biotransformation Half-Life (days) : 8.85 (normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): 4.39 (BAF = 2.46e+004 L/kg wet-wt)
Log Kow (experimental): not available from database
Log Kow used by BCF estimates: 7.54
Equation Used to Make BCF estimate:
Log BCF = -0.49 log Kow + 7.554 + Correction
Correction(s): Value
No Applicable Correction Factors
Estimated Log BCF = 3.861 (BCF = 7255 L/kg wet-wt)
===========================================================
Whole Body Primary Biotransformation Rate Estimate for Fish:
===========================================================
------+-----+--------------------------------------------+---------+---------
TYPE | NUM | LOG BIOTRANSFORMATION FRAGMENT DESCRIPTION | COEFF | VALUE
------+-----+--------------------------------------------+---------+---------
Frag | 1 | Linear C4 terminal chain [CCC-CH3] | 0.0341 | 0.0341
Frag | 2 | Unsubstituted phenyl group (C6H5-) | -0.6032 | -1.2064
Frag | 10 | Aromatic-H | 0.2664 | 2.6638
Frag | 2 | Methyl [-CH3] | 0.2451 | 0.4902
Frag | 5 | -CH2- [linear] | 0.0242 | 0.1209
Frag | 1 | -CH- [linear] | -0.1912 | -0.1912
Frag | 2 | Benzene | -0.4277 | -0.8555
L Kow| * | Log Kow = 7.54 (KowWin estimate) | 0.3073 | 2.3166
MolWt| * | Molecular Weight Parameter | | -0.8883
Const| * | Equation Constant | | -1.5058
============+============================================+=========+=========
RESULT | LOG Bio Half-Life (days) | | 0.9472
RESULT | Bio Half-Life (days) | | 8.855
NOTE | Bio Half-Life Normalized to 10 g fish at 15 deg C |
============+============================================+=========+=========
Biotransformation Rate Constant:
kM (Rate Constant): 0.07828 /day (10 gram fish)
kM (Rate Constant): 0.04402 /day (100 gram fish)
kM (Rate Constant): 0.02475 /day (1 kg fish)
kM (Rate Constant): 0.01392 /day (10 kg fish)
Arnot-Gobas BCF & BAF Methods (including biotransformation rate estimates):
Estimated Log BCF (upper trophic) = 2.624 (BCF = 420.7 L/kg wet-wt)
Estimated Log BAF (upper trophic) = 4.392 (BAF = 2.464e+004 L/kg wet-wt)
Estimated Log BCF (mid trophic) = 2.766 (BCF = 583.5 L/kg wet-wt)
Estimated Log BAF (mid trophic) = 4.751 (BAF = 5.636e+004 L/kg wet-wt)
Estimated Log BCF (lower trophic) = 2.809 (BCF = 644.9 L/kg wet-wt)
Estimated Log BAF (lower trophic) = 4.967 (BAF = 9.263e+004 L/kg wet-wt)
Arnot-Gobas BCF & BAF Methods (assuming a biotransformation rate of zero):
Estimated Log BCF (upper trophic) = 3.789 (BCF = 6147 L/kg wet-wt)
Estimated Log BAF (upper trophic) = 7.160 (BAF = 1.447e+007 L/kg wet-wt)
Applicant's summary and conclusion
- Conclusions:
- regression-based method.
- Executive summary:
The modelled BCF values for 2 -EHDPP are quite high but likely to be of little value or reliability as these estimates do not consider hydrolysis or biotranformation of the substance, both of which are expected to be high. Actual testing of this substance for BCF is not feasible given the rapid hydrolysis and very low water solubility. The BCF of phenol (the primary hydrolysis product) is 17.5 L/Kg (EU Phenol RAR 2006) and the BCF of 2 -ethylhexanol is 25.33 L/kg (EPISuite 4.0).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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