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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 200-657-5 | CAS number: 67-51-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
Hydrolysis:
The half-life for hydrolysis was determined to be > 1 year at 25 ºC for 3,5-Dimethylpyrazole from pH 4 to 9. This was determined in a key study (Baltussen, 2012) which was performed in line with GLP and to the standardised guidelines OECD 111, EU method C.7 and EPA OPPTS 835.2120.
Biodegradation:
The biodegradability of 3,5-Dimethylpyrazole was determined in a key study (Kelly & Clayton, 2003) performed in line with GLP and to the standardised guidelines OECD 1301 A and EU method C.4 A. The test material was determined to be not readily biodegradable.
In accordance with Column 2 (specific rules for adaptation from Column 1) of Annex IX of Regulation (EC) No. 1907/2006, further degradation testing shall only be considered if the Chemical Safety Assessment indicates the need to investigate further the degradation of the substance.
The soil simulation testing (for substances with a high potential for adsorption to soil) test required under information point 9.2.1.3 does not need to be conducted since direct and indirect exposure of soil is unlikely. The identified uses of the substance are not likely to result in exposure to soil.
Bioaccumulation:
In accordance with Column 2 (specific rules for adaptation from Column 1) of Annex IX of Regulation (EC) No. 1907/2006, the bioaccumulation is aquatic species study, required under information point 9.3.2, can be omitted if direct and indirect exposure of the aquatic compartment is unlikely. No exposure to the aquatic environment is predicted, therefore testing is not required.
Transport and distribution:
The adsoption coefficient (Koc) for the substance was determined to be 1.2 x 105, giving a log Koc of 5.1. This large adsorption coefficient value demonstrates very little to no mobility through the soil of the chemical.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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