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Diss Factsheets
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EC number: 211-932-4 | CAS number: 713-95-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- delta–dodecalactone.
- Author:
- D.L.J.Opdyke
- Year:
- 1 979
- Bibliographic source:
- Food and Cosmetics Toxicology, Volume 17, Supplement, December 1979, Pages 773-774
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Maximization test
- Principles of method if other than guideline:
- A maximization test was performed to determine the sensitization potential of the test chemical
- GLP compliance:
- not specified
- Type of study:
- other: Maximization test
- Justification for non-LLNA method:
- Currently no LLNA study is available for assessment.
Test material
- Reference substance name:
- Dodecan-5-olide
- EC Number:
- 211-932-4
- EC Name:
- Dodecan-5-olide
- Cas Number:
- 713-95-1
- Molecular formula:
- C12H22O2
- IUPAC Name:
- 6-heptyloxan-2-one
- Test material form:
- liquid
- Details on test material:
- - Name of the test material : Dodecan 5- olide
- Molecular formula : C12H22O2
- Molecular weight : 198.31 g/mol
- Substance type : Organic
- Physical state : Liquid
Constituent 1
In vivo test system
Test animals
- Species:
- other: humans
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 12% in petrolatum
- Adequacy of induction:
- not specified
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 12% in petrolatum
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- 30
- Details on study design:
- no data available
- Challenge controls:
- no data available
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 12% in petrolatum
- No. with + reactions:
- 0
- Total no. in group:
- 30
- Clinical observations:
- No dermal reactions observed
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- The test chemical 12% in petrolatum did not induce any sensitization reactions on the skin of 30 human volunteers. Hence, the test chemical was considered to be not sensitizing to skin.
- Executive summary:
A human maximization test was carried out to assess the dermal sensitization potential of the test chemical. The test chemical 12% in petrolatum was applied to the skin of 30 human volunteers and observed for signs of dermal sensitization (duration of exposure, observation period not specified).
The test chemical 12% in petrolatum did not induce any sensitization reactions on the skin of 30 human volunteers. Hence, the test chemical was considered to be not sensitizing to skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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