Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-126-1 | CAS number: 10042-59-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
- acute oral:
rat (male/female): LD50 = 5400 mg/kg bw (TSCAT, OTS 0538594, Doc I.D. 88-920007511, Monsanto Company, 1979; reliable with restrictions)
- acute inhalative:
rat (male/female): IRT, no mortality after the 8 hour-exposure to saturated vapor (at 20°C) (Smyth, H.F. et al., 1962; reliable with restrictions)
- acute dermal:
rabbit (male/female): LD50 > 5100 mg/kg bw (TSCAT, OTS 0538594, Doc I.D. 88-920007511, Monsanto Company, 1979; reliable with restrictions)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Principles of method if other than guideline:
- Administration of a single oral dose of the test substance to Sprague-Dawley rats to determine the acute oral toxicity.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-Propylheptanol
- Lot/batch No.: NBP 1282594-A - Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males: 235 - 250 g, females: 235-245 g; - Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5010, 6310, 7940, 10000 mg/kg
- No. of animals per sex per dose:
- 5 animals per dose (males and females)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 400 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 5 020 - <= 5 780
- Mortality:
- - 5010 mg/kg bw: males: 0/2, females: 1/3;
- 6310 mg/kg bw: males: 3/3, females: 2/2;
- 7940 mg/kg bw: males: 2/2, females: 3/3;
- 10000 mg/kg bw: males: 3/3, females: 2/2;
Deaths occurred between days 2 - 5 - Clinical signs:
- other: Increasing weakness, ocular discharge, diarrhea, collapse
- Gross pathology:
- Decedents: Hemorrhagic lungs, liver discoloration, and acute gastrointestinal inflammation;
Survivors: Viscera appeared normal; - Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to the results of the study a LD 50 value of 5400 mg/kg bw was established under these test conditions. Therefore no classification according to EU or GHS criteria is required.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 400 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given.
- Principles of method if other than guideline:
- Concentrated vapor inhalation was performed exposing groups of 6 male or female albino rats to a flowing stream of vapor-loaded air. The vapor-air mixture was generated by passing 2.5 l/min of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in approximately 50 ml of the test substance in a gas-washing bottle. Inhalations were continued for 8 hours in a logarithmic series. The observation period lasted 14 days.
- GLP compliance:
- no
- Test type:
- other: inhalation risk test
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-Propylheptanol
- Analytical purity: not stated - Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Source and rate of air: 2.5 l/min - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- 0.130 mg/l (vapor saturation)
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- ca. 0.13 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: IRT: the test concentration (saturated vapor) was calculated by means of the vapor pressure at 20°C and the molecular weight
- Mortality:
- No mortality after 8 hours exposure.
- Clinical signs:
- other: no data
- Body weight:
- no data
- Gross pathology:
- no data
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 0.13 µg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Principles of method if other than guideline:
- Application of a single dermal dose of the test substance to the skin of male and female New Zealand Albino Rabbits for 24 h to determine the acute dermal toxicity.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-Propylheptanol
- Lot/batch No.: NBP 1282594-A - Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males: 1.8 kg, females: 1.9 - 2.0 kg - Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 3160, 5010, 7940 mg/kg bw
- No. of animals per sex per dose:
- - 3160 mg/kg: 1 male animal;
- 5010 mg/kg bw: 1 female animal;
- 7940 mg/kg bw: 1 male and 1 female animal; - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 010 mg/kg bw
- Based on:
- test mat.
- Mortality:
- - 3160 mg/kg bw: 0/1 (male animal);
- 5010 mg/kg bw: 0/1 (female animal);
- 7940 mg/kg bw: male animal: 1/1; female animal: 0/1;
Deaths occurred on day 2. - Clinical signs:
- other: Increasing weakness, diarrhea, collapse.
- Gross pathology:
- Decedents: Hemorrhagic areas of the lungs, liver and spleen discoloration, enlarged gall bladder, darkened kidneys, and gastrointestinal inflammation;
Survivors: Viscera appeared normal; - Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to the results of the study a LD 50 value > 5010 mg/kg bw was established under these test conditions. Therefore no classification according to EU or GHS criteria is required.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 010 mg/kg bw
Additional information
Oral:
Acute oral toxicity was evaluated in a study which was reliable with restrictions. Groups of 5 male and 5 female Sprague-Dawley rats received doses of 5010, 6310, 7940 or 10000 mg/kg bw of 2-Propylheptan-1-ol (TSCAT, OTS 0538594, Doc I.D. 88-920007511, Monsanto Company, 1979). Clinical signs included: increasing weakness, ocular discharge, diarrhea, collapse. Due to the observed mortality (2 - 5 days after administration) LD50 of 5400 mg/kg bw (male and female animals) was estimated.
Inhalative:
Data of the acute inhalative toxicity of CAS 10042-59-8 is restricted to an inhalation risk test (reliable with restrictions) with limited reporting (Smyth, H.F. et al., 1962).
Concentrated vapor inhalation was performed exposing groups of 6 male or female albino rats to a flowing stream of vapor-loaded air. The temperature at vapor generation was room temperature.
Vapor saturation at 20°C is 0.130 mg/l (vapor pressure (20°C): 0.02 hPa). Inhalations were continued for 8 h. The observation period lasted 14 days. After the 8 hour-exposure no mortality occurred. No information on clinical signs was given.
Dermal:
Acute dermal toxicity was analyzed in a study (reliable with restrictions), where New Zealand White rabbits received a dermal application of 3160 (1 male animal), 5010 (1 female animal) or 7940 mg/kg bw (1 male and 1 female animal) of 2-Propylheptan-1-ol for 24 hours (TSCAT, OTS 0538594, Doc I.D. 88-920007511, Monsanto Company, 1979). Clinical signs were: increasing weakness, diarrhea, collapse. Only the male animal of the 7940 mg/kg bw group died. Therefore, a LD 50 > 5010 mg/kg bw was established.
All described studies were conducted before the implementation of GLP and OECD Guidelines.
Justification for classification or non-classification
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for acute toxicity under Regulation (EC) No. 1272/2008, as amended for the tenth time in Regulation (EU) No 2017/776.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.