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Diss Factsheets
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EC number: 235-330-6 | CAS number: 12167-74-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Follows basic scientific principles. Not a toxicological study, but provides supporting data to suggest monocalcium phosphate is well tolerated in the diets of fish.
Data source
Reference
- Reference Type:
- publication
- Title:
- Dietary phosphorus requirement of juvenile haddock (Melanogrammus aeglefinus L.)
- Author:
- Roy PK & Lall SK
- Year:
- 2 003
- Bibliographic source:
- Aquaculture. 221: 451–468
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A study was conducted to determine the quantitative requirement, excretion, availability and deficiency signs of phosphorus in haddock. Triplicate groups of haddock (4.2F0.01 g) were fed diets containing 0.42, 0.62, 0.82, 1.02 and 1.22% P and 19 MJ digestible energy (DE) per g of diet to satiation for 12 weeks. The basal diet, containing 0.42% P (0.08 g available P per MJ DE), was supplemented with graded levels of calcium phosphate, Ca(H2PO4)2. H2O, to formulate the five experimental diets.
- GLP compliance:
- not specified
- Type of study / information:
- Availability of phosphorus from monocalcium phosphate as a food additive for fish. Indicates a low potential for toxicity.
Test material
- Reference substance name:
- Calcium bis(dihydrogenorthophosphate)
- EC Number:
- 231-837-1
- EC Name:
- Calcium bis(dihydrogenorthophosphate)
- Cas Number:
- 10031-30-8
- Molecular formula:
- H6CaO9P2
- IUPAC Name:
- calcium diphosphate hydrate
- Details on test material:
- - Name of test material (as cited in study report): calcium phosphate
- Molecular formula (if other than submission substance): Ca(H2PO4)2
Constituent 1
Results and discussion
Any other information on results incl. tables
The growth, feed conversion ratio, vertebrae and opercula ash and urinary phosphate excretion were positively correlated with dietary phosphorus levels. Vertebrae ash increased from 44.5% to 56.6 ± 0.47% and operculum ash from 31.4% to 48.2 ± 0.56% of fat free dry matter with increasing dietary phosphorus content. Phosphorus requirement was estimated by using a quadratic equation for vertebrae ash. The data suggest that a diet of 0.96% total phosphorus, or 0.72% available phosphorus or 0.34 g available phosphorus per MJ DE, is required for haddock fingerlings. Plasma and urinary phosphate excretion increased with increasing dietary phosphorus levels and ranged from 0.4– 1.5 ± 0.03 to 0.1–7.9 ± 0.2 mmol- l, respectively. Inorganic phosphorus was highly available (99 ± 1.23%). Signs of phosphorus deficiency were characterized by poor growth, loss of appetite, poor bone mineralization, deformed vertebrae and an increase in body lipid content.
Applicant's summary and conclusion
- Conclusions:
- It is obvious from these results that P is essential for growth, efficient feed utilization and bone mineralization of haddock. Excess P not only causes excessive excretion of this element but it also has a negative effect on bone mineralization.
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