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EC number: 612-934-1 | CAS number: 620176-90-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 June 2016 - 29 November 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- 1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethan-1-one
- Cas Number:
- 620176-90-1
- Molecular formula:
- C11H11FO2
- IUPAC Name:
- 1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethan-1-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study reports): JNJ-7928531-AAA (T001481)
- Physical state: liquid
- Appearance: Colourless, light yellow to brown liquid
Constituent 1
- Specific details on test material used for the study:
- - Batch n°: M16AB0419
- Expiration date: 23 September 2016
- Purity: 102.5% (based on GC assay)
- Storage condition of test material: at room temperature
Results and discussion
Melting / freezing point
- Key result
- Melting / freezing pt.:
- -65.5 °C
- Atm. press.:
- 1 013.25 hPa
- Decomposition:
- yes
- Decomp. temp.:
- > 175 °C
- Remarks on result:
- other: During the test no melting was observed.
- Remarks:
- Glass transition temperature is reported
Any other information on results incl. tables
Preliminary test
From the TGA curve it could be derived that the weight of the sample decreased significantly at 175°C. At 265°C the sample weight has decreased by 25%.
After the experiment it was observed that the test item was evaporated from the sample container.
Main tests
During cooling a glass transition was observed between -85°C and -60°C. During heating a glass transition between -75°C and -50°C was observed. The inflection point of the glass transition was -65.417°C. An endothermic peak between 200°C and 300°C was observed. The extrapolated onset temperature of the peak was 276.807°C. The effect was most likely obtained due to boiling of the test item. After the experiment it was observed that the test item was evaporated from the sample container.
Experiment 2 was performed to investigate the boiling point and is explained in the next section.
Experiment 3 was performed to investigate reaction and/or decomposition of the test item and was therefore
stopped at 280°C. At approximately 110°C a small signal was observed: it was most likely an artefact. From 175°C the baseline deviated in the endothermic direction. After the experiment, a light yellow residue remained in the sample container which demonstrated that reaction and/or decomposition of the test item probably took place over the temperature range.
The glass transition temperature was determined as the average glass transition temperature obtained from experiment 1 (-65.417°C) and experiment 2 (-65.586°C). No melting was observed.
Applicant's summary and conclusion
- Conclusions:
- The glass transition temperature of JNJ-7928531-AAA (T001481) was determined at -65.5°C (207.6K) by using DSC.
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