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Diss Factsheets
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EC number: 811-683-7 | CAS number: 1799707-26-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation))
- Deviations:
- yes
- Remarks:
- Temperature range was 22-23oC
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Test item: 4,4'-(1-phenylethane-1,1-diyl)bis(heptyloxybenzene)
Solubility and stability of the test substance in solvent/vehicle: Sparingly soluble in water
Purity: 99.56%
Purity test date: 01.02.2016
Test item storage: Room temperature
Stability under storage conditions: 21 March 2012 (expiry date) - Analytical monitoring:
- not required
- Vehicle:
- no
- Details on test solutions:
- Test item mixed with Milli-RO water, synthetic medium and activated sludge to achieve nominal test loading rate of 10, 100 and 1000 mg/L
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Hardness:
- No data
- Test temperature:
- Nominal test temperature 20 +/- 2oC
Measured temp 22-23 oC
This deviation was not considered to adversely affect the study integrity - pH:
- 7.6-7.7 (start)
7.6-8.1 (end) - Dissolved oxygen:
- >60% saturation at start (>5 mg/L)
- Salinity:
- No data
- Conductivity:
- No data
- Nominal and measured concentrations:
- Nominal loading rate 10, 100 and 1000 mg/L as test item
- Reference substance (positive control):
- yes
- Key result
- Duration:
- 3 h
- Dose descriptor:
- other: ELR50
- Remarks:
- Effect loading rate
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Key result
- Duration:
- 3 h
- Dose descriptor:
- other: NOELR
- Remarks:
- No observed effect loading rate
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item did not inhibit the respiration rate of activated sludge at a loading rate of 1000 mg/L, under the conditions of the test
- Executive summary:
A reliable study to determine the activated sludge respiration inhibition for the test substance was conducted in accordance with OECD test guideline 209 and in compliance with GLP.
Under the conditions of the test, the test item was not toxic to waste water bacteria (activated sludge) after 3 hours incubation at a nominal loading rate of 1000 mg/L. The ELR50 and NOELR were both >1000 mg/L. This value is greater than the limit of solubility of the test substance.
This study is considered acceptable and satisfies the guideline requirements for a toxicity to microorganisms study.
Reference
Type of bottle |
Nominal loading rate (mg/L) |
pH |
Respiration rate (mg O2/g/h) |
% inhibition (mean value) |
|
Start |
End |
||||
Control |
0 |
7.6-7.7 |
7.6-7.8 |
43.4 |
- |
Reference item |
2 |
7.7 |
8.1 |
25.7 |
41 |
Reference item |
4 |
7.7 |
8.1 |
22.8 |
48 |
Reference item |
8 |
7.7 |
8.0 |
20.2 |
54 |
Reference item |
16 |
7.7 |
8.0 |
11.3 |
74 |
Test item |
10 |
7.7 |
7.6 |
50.3 |
-16 |
Test item |
100 |
7.6 |
7.6 |
38.8 |
11 |
Test item |
1000 |
7.6 |
7.5-7.6 |
46.2 |
-6 |
Abiotic control |
1000 |
7.6 |
7.4 |
0.9 |
99 |
Description of key information
A reliable study (Klimisch 1) to determine the activated sludge respiration inhibition for the test substance was conducted in accordance with OECD test guideline 209 and in compliance with GLP.
Under the conditions of the test, the test item was not toxic to waste water bacteria (activated sludge) after 3 hours incubation at a nominal loading rate of 1000 mg/L. The ELR50 and NOELR were both >1000 mg/L. The toxicity value is greater than the limit of solubility of the test substance.
The test validity criteria were met and there were no significant deviations noted to affect the integrity of the study. This study is considered acceptable and satisfies the guideline requirements for a toxicity to microorganisms study.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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