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Diss Factsheets
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EC number: 201-873-2 | CAS number: 88-99-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation, other
- Remarks:
- respiratory allergenicity test in guinea pigs
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined. No purity of test substance defined.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
- Principles of method if other than guideline:
- respiratory allergenicity test in guinea pigs: Briefly, guinea pigs were individually housed in whole body plethysmogryphs connected to a Model DP103 ultralow range differential pressure transducer. respiratory rate and peak height (change in pressure) from each animal were continuously monitored on a ZF-8000 chart recorder interfaced with an IBM PC/AT computer. One group of five guinea pigs and one group of six guinea pigs were exposed for 3 hr/day for 5 consecutive days to Phthalic Acid (PA) dust ranging between 0.05 to 0.2 mg/m³ and 0.6 to 6 mg/m³ respectively. PA concentrations were chosen to bracket the published threshold limit value (TLV) for PA (6.0 mg/m³; ACGIH, 1990). Two weeks after the last chemical exposure, air control (eight animals) and chemical exposed animals were challenged for 30 min with aerosolized chemical-GPSA conjugate (95% respirable). Respiratory baseline measurements were made for 30 min preexposure to challenge antigen. Significant respiratory reactions to challenge antigen were defined as increases in breath peak height and/or respiratory rate that were greater than 3 standard deviations from the mean change in the same parameters of control animals exposed to chemical-protein conjugate. These responses must be sustained for at least 5 min in order to be scored as positive.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phthalic acid
- EC Number:
- 201-873-2
- EC Name:
- Phthalic acid
- Cas Number:
- 88-99-3
- Molecular formula:
- C8H6O4
- IUPAC Name:
- benzene-1,2-dicarboxylic acid
- Details on test material:
- phthalic acid (Fisher Scientific, Fair Lawn, NJ), No purity defined.
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- female
Test system
- Route of induction exposure:
- inhalation
- Route of challenge exposure:
- inhalation
- Vehicle:
- not specified
- Concentration:
- no data
- No. of animals per dose:
- 10
Results and discussion
Any other information on results incl. tables
Specific Serum Antibody Titers and percentage of animals with respiratory Reactivity to Chemical-GPSA Conjugate: Injection with Equimolar Doses of Chemical:
Phthalic Acid | Respiratory reactivity (Consecutive contractions every 36 -40 normal breaths after IT challange with conjugate) | Mean ELIZA titer (+SE) (Titers were defined as the reciprocal of the highest dilution of sera yielding positive responses in ELISA or PCA test. | Mean PCA titer (+SE) |
6.7x10-4M | 0% (0/10) | 0 | 0 |
Applicant's summary and conclusion
- Executive summary:
In an respiratory allergenicity test in female hartley guinea pigs the test substance prooved to be non-sensitizing.
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