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Diss Factsheets
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EC number: 209-143-5 | CAS number: 556-88-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Nitroguanidine is of low toxicity to water or soil organism. It does not need to be classified for environment.
Additional information
The test substance nitroguanidine is not toxic to aquatic organisms with fish and daphnia acute toxicity (L/EC50) > 100 mg/L, fish long term toxicity (28-day ELS test NOEC with Pimephales promelas) > 100 mg/L, daphnia long term toxicity (reproduction NOEC) of 260 mg/L, and a 5-day algal toxicity (growth EC50) of 2146 mg/L. Nitroguanidine is not toxic to activated sludge microorganisms as the test substance did not influence respiration rates to any extent up to concentrations to 300 mg/L.
Besides test with nitroguanidine, also tests with photolyzed nitroguanidine have been conducted:
Photolyzed nitroguanidine is of higher toxicity than nitroguanidine. The short-term toxicity for fish (96h LC50) and daphnia (48h EC50) is 34.5 mg/L for Fathead minnow (P. promelas) and 24.6 mg/L for Daphnia magna, respectively. Photolysis increased the acute toxicity for D. magna by a factor from over 115.
In a test conducted for long-term toxicity to aquatic invertebrates, photolysis of nitroguanidine resulted in significant mortality (α= 0.05) to the adults occurred at all nominal test concentrations down to 3.6 mg/L. The LOEC and NOEC of photolyzed nitroguanidine for the daphnids, based on the survival of the adults, were 3.6 mg/L and 2.2 mg/L (nominal concentrations), respectively. Photolyzed nitroguanidine was approximately two orders of magnitude more toxic to daphnids than the parent compound under the same test conditions.
The 5-day EC50 in the green algae Raphidocelis subcapitata, formerly known as Selenastrum capricornutum and Pseudokirchneriella subcapitata for photolyzed nitroguanidine is approximately 32.3 mg/L. Photolysis increased the acute toxicity by a factor of 66.4.
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