Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-431-8 | CAS number: 615-50-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Summary:
PTD is an oxidative dye molecule which reacts during product use. This is e.g. the case during hair coloring processes. Furthermore from hair product formulation manufacturing sites PTD is disposed to waste water treatment plants as a results of washing and cleaning processes of batch container and other technical equipment’s. Our knowledge of PTD oxidation suggests that the reaction of PTD does not lead to loss of the material from toxicity test solutions via volatilization, sorption to containers, or biodegradation. We suspect that PTD is transformed to reactants which remain in the toxicity test. Given the need in REACH to include transformation products in safety evaluations and the need to be conservative in the environmental assessment, it is proposed to base the PNEC on toxicity test endpoints derived from nominal concentrations to best reflect the fact that toxicity is being caused by both PTD and PTD transformation products.
Rational:
During environmental aquatic toxicity studies PTD measured concentrations were are typically significantly below the nominal concentrations. E.g. in one of the aquatic semi-static daphnia study PTD measured concentrations were 55-76% of nominal (renewal at 24 hours). Another aquatic acute tox study with algae the PTD measured concentrations were 9-25% of nominal (no renewal over 72 hours).
Toxicity testing of PTD in the presence of a stabilizer – here ascorbic acid - showed that PTD is less toxic than degradation products which where formed during toxicity tests duration. Fish Embryo testing (FET, OECD draft guideline 236) with PTD in the presence of 0.04% ascorbic acid showed that PTD is not toxic at a concentration of up to 2 mg/L. In the absence of the stabilizer ascorbic acid, PTD has an LC50 less than 1 mg/L in the FET test.
Biodegradation testing demonstrates slow conversion of PTD to CO2 (17% CO2 in 28 days). Thus, we expect that removal during the aerobic sewage treatment simulation test is a result of PTD primary degradation (i.e., oxidative reaction with itself to form dimers and trimers and reaction with other components of the synthetic sewage feed and the activated sludge).
Based on the above, we can summarize that PTD is an oxidative dye molecule which reacts during product use. This is e.g. the case during hair coloring processes. Furthermore from hair color product formulation manufacturing site PTD is disposed to waste water treatment plants as a results of washing and cleaning processes of batch container and other technical equipment’s. We know that the reaction of PTD does not lead to significant loss of the material from solution via volatilization, sorption to containers, or biodegradation. We suspect that PTD is transformed to reactants which remain in the toxicity test. Given the need in REACH for us to include transformation products in our safety evaluation and the need to be conservative in the environmental assessment, it is proposed to base the PNEC on toxicity test endpoints derived from nominal concentrationsto best reflect the fact that toxicity is being caused by both PTD and PTD transformation products.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.