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Diss Factsheets
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EC number: 200-751-6 | CAS number: 71-36-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- behavioural effects
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Concentration-dependent behavioral changes in mice following short-term inhalation exposure to various industrial solvents
- Author:
- De Ceaurriz J.C. et al.
- Year:
- 1 983
- Bibliographic source:
- Toxicol. appl. Pharmacol. 67, 383- 389 (1983); citred in Environmental Health Criteria 65, Butanols (1987)
Materials and methods
- Principles of method if other than guideline:
- Male mice were tested in a "behavioural despair" swimming test after inhalative exposure.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- neurotoxicity
Test material
- Reference substance name:
- Butan-1-ol
- EC Number:
- 200-751-6
- EC Name:
- Butan-1-ol
- Cas Number:
- 71-36-3
- Molecular formula:
- C4H10O
- IUPAC Name:
- butan-1-ol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Remarks:
- OF1 mice
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: IFFA CREDO, Domaine des Oncins, Saint-Germain-sur-I'Arbresle, France
- Weight at study initiation: 20-25g
- Diet (e.g. ad libitum): food (UAR-Alimentation,Villemoisson, France) ad libitum
- Water (e.g. ad libitum):ad libitum
- Acclimation period: 7days
Administration / exposure
- Route of administration:
- inhalation: vapour
- Details on exposure:
- Exposures were conducted in 200-liter (stainless steel) inhalation chambers designed to sustain dynamic and adjustable
flows of air (10 to 30 m' per hour) . To prevent leakage of the test atmospheres into the room, the chambers
were maintained at a negative Pressure of 1 to 2 mm H2O,relative to the room.The vapors of the test compounds
were injected at the entry of the inhalation chambers.
For generation of organic compound-air mixtures, two systems were utilized ; an injector was employed and heat was added as needed to obtain the vaporization of the substances, or vapors were produced by bubbling an additional air flow through a vial containing the liquid compound . Under both conditions, the vaporized compound was carried into a mixing device for further diIution with air to the final concentration before entering the exposure chamber. - Duration of treatment / exposure:
- 4 h
- Frequency of treatment:
- single
Doses / concentrationsopen allclose all
- Dose / conc.:
- 470 ppm
- Remarks:
- 1446.7 mg/m3
- Dose / conc.:
- 548 ppm
- Remarks:
- 1686.7mg/m3
- Dose / conc.:
- 844 ppm
- Remarks:
- 2597.8 mg/m3
- Dose / conc.:
- 965 ppm
- Remarks:
- 2970.2 mg/m3
- No. of animals per sex per dose:
- 10 males/ treatment
- Control animals:
- yes
- Details on study design:
- At the end of each exposure period:
- mouse immersed inside a vertical glass cylinder placed in a macrolon cage containing 10 cm of water at 21 to 23°C
- total duration of immobility observed during the first 3 min after plunging the mouse in water measured
- mouse was judged to be immobile when it ceased struggling and remained floating passively in the water in a semihorizontai position only making movements necessary to keep its head above the water.
Results and discussion
- Details on results:
- Compared with controls, a dose-related decrease in the duration of immobility measured over a 3-min period was observed (see table).The mean active atmospheric concentration associated with a 50% decrease in immobility (ID50) for n-butanol was determined to be 617 ppm [95% confidence interval 547-681].
Any other information on results incl. tables
exposure concentration (ppm) | control groups (duration of immobility) |
exposed groups (duration of immobility) |
Percentage change |
470 | 91.9±6.3 | 56.6± 8.0 * | -38 |
548 | 100.9± 5.3 | 53.2± 2.5 * | -47 |
844 | 92.8± 7.7 | 37.1± 10.5* | -60 |
965 | 79.2± 5.9 | 24.0± 4.9 * | -70 |
The values given are the mean durations ±SE obtained from 10 animals and expressed in sec.
*Significantly different from the respective control values, p < 0 .05
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.