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Diss Factsheets
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EC number: 204-661-8 | CAS number: 123-91-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- BASF-Test
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,4-dioxane
- EC Number:
- 204-661-8
- EC Name:
- 1,4-dioxane
- Cas Number:
- 123-91-1
- Molecular formula:
- C4H8O2
- IUPAC Name:
- 1,4-dioxane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation (mean): 226 g (males); 197 g (females)
ENVIRONMENTAL CONDITIONS
no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 30 %, 16 %, and 2 % (v/v)
MAXIMUM DOSE VOLUME APPLIED: 6 mL/animal
- Doses:
- 200, 1600, 3200, 4000, 5000, and 6400 µL/kg bw (corresponding to approx. 206, 1648, 3296, 4120, 5150, and 6592 mg/kg bw) (recalculation of doses based on relative density of 1.03)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Weighing was performed only at the beginning of the study for dose calculation. Observation of clinical signs was performed several times on the day of administration and once daily afterwards with the exception of weekends and on holidays.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, pathology - Statistics:
- No statistics were performed.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 150 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 6592 mg/kg bw: 10/10 animals died within 48 hours
5150 mg/kg bw: 5/10 animals died within 7 days
At the lower doses between 4120 and 206 mg/kg bw no mortality was observed. - Clinical signs:
- other: 6592 mg/kg bw: immediately after administration accelerated respiration, squatting posture and in some animals abdominal position were observed. After 5 min atony and apathy, after 10 min abdominal and lateral position, back posture, eye discharge and nar
- Gross pathology:
- Deceased animals:
- heart: acute dilatation; lungs: venous hyperemia, slightly edematous; stomach: bloody ulcerations; intestines: hematinized black contents, diarrheic; liver: pale; kidneys: pale; blood: coagulopathy.
Sacrificed animals:
- without abnormalities.
Any other information on results incl. tables
Mortality:
|
Dead animals / treated animals after |
|||||
Dose (mg/kg bw/d) |
Conc. (%) |
No of animals |
1 h |
24 h |
48 h |
7 d |
6592 |
30 |
5 males |
0/5 |
1/5 |
5/5 |
5/5 |
5 females |
0/5 |
3/5 |
5/5 |
5/5 |
||
5150 |
30 |
5 males |
0/5 |
0/5 |
0/5 |
0/5 |
5 females |
0/5 |
1/5 |
1/5 |
5/5 |
||
4120 |
30 |
5 males |
0/5 |
0/5 |
0/5 |
0/5 |
5 females |
0/5 |
0/5 |
0/5 |
0/5 |
||
3296 |
30 |
5 males |
0/5 |
0/5 |
0/5 |
0/5 |
5 females |
0/5 |
0/5 |
0/5 |
0/5 |
||
1648 |
16 |
5 males |
0/5 |
0/5 |
0/5 |
0/5 |
5 females |
0/5 |
0/5 |
0/5 |
0/5 |
||
206 |
2 |
5 males |
0/5 |
0/5 |
0/5 |
0/5 |
5 females |
0/5 |
0/5 |
0/5 |
0/5 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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