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Diss Factsheets
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EC number: 207-988-4 | CAS number: 504-29-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity. Weight of evidence. Based on the available information (peer reviewed handbook data), the oral LD50 in rats is 200 mg/kg bw.
Acute inhalation toxicity. No study available. Supporting data: According to handbook data, a tolerance of 0.5 ppm in humans has been reported.
Acute dermal toxicity. Supporting study. The LD50 of the test item in guinea pigs is 500 mg/kg bw, according to peer reviewed handbook data.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Data from peer reviewed handbook. No data provided on methods.
- GLP compliance:
- not specified
- Test type:
- other: not specified.
- Specific details on test material used for the study:
- - pyridin-2-amine / 504-29-0 / 207-988-4
- State: powder - Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 200 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- EU criteria
- Conclusions:
- According to handbook data, the oral DL50 for rat is 200 mg/kg bw.
- Executive summary:
According to 'Sax's Dangerous Properties of Industrial Materials', 11th edition, 'Kirk-Othmer Encyclopedia of Chemical Technology', and Patty’s Toxicology, 6th Edition, (peer reviewed handbook data), the oral DL50 for rat is 200 mg/kg bw.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Data from peer reviewed handbook. No data provided on methods.
- GLP compliance:
- not specified
- Test type:
- other: not specified.
- Specific details on test material used for the study:
- pyridin-2-amine
- Species:
- other: human
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- other: TCLo
- Effect level:
- 0.5 other: ppm
- Based on:
- test mat.
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- EU criteria.
- Conclusions:
- According to handbook data, the test item is highly toxic by ingestion and inhalation. Tolerance: 0.5ppm.
- Executive summary:
According to 'The condensed chemical dictionary', 8th edition (peer reviewed handbook data), the test item is highly toxic by ingestion and inhalation. Tolerance: 0.5 ppm.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Data from peer reviewed handbook. No data provided on methods.
- GLP compliance:
- not specified
- Test type:
- other: not specified.
- Limit test:
- no
- Species:
- other: quail
- Strain:
- other: Coturnix coturnix
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: wild
- Fasting period before study: no
- Housing: individually caged
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 2-6 weeks. - Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 175 µL
- Doses:
- Not specified.
- No. of animals per sex per dose:
- 4-6 animals per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Observations: Data recorded included affectation time, induction and duration of immobilization, mortality, regurgitation, weight gain or loss, and any unique pliysiological effects.
- Frequency of observations and weighing: daily observations.
- Necropsy of survivors performed: no - Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 133 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- EU criteria.
- Conclusions:
- According to handbook data, the oral LD50 for quail is 133 mg/kg bw.
- Executive summary:
According to 'The dictionary of substance and their effects', and 'Sax's Dangerous Properties of Indutrial Materials', 11th edition (peer reviewed handbook data), based on an acute oral toxicity study on quail (Coturnix coturnix), the oral LD50 for quail is 133 mg/kg bw.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No data on methods.
- GLP compliance:
- not specified
- Remarks:
- data from handbook, no further information provided.
- Test type:
- other: not specified.
- Limit test:
- no
- Specific details on test material used for the study:
- 2-aminopyridine
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 50 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- EU criteria.
- Conclusions:
- According to handbook data, the oral LD50 for mice is 50 mg/kg bw.
- Executive summary:
According to 'Patty’s Toxicology', 6th edition (peer reviewed handbook data), the oral LD50 for mice is 50 mg/kg bw.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 200 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- Data from peer reviewed handbook. No data provided on methods.
- GLP compliance:
- not specified
- Test type:
- other: not specified.
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Control animals:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 500 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- EU criteria.
- Conclusions:
- The LD50 of the test item is ca. 500 mg/kg.
- Executive summary:
As reported in 'Patty's Toxicology', 6th edition (peer reviewed handbook data), dermal absorption in guinea pigs occurs readily for the test item, as indicated by an approximate LD50 of 500 mg/kg; deaths were accompanied by convulsions.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 000 mg/kg bw
Additional information
Acute Oral Toxicity: According to 'Sax's Dangerous Properties of Industrial Materials', 11th edition, 'Kirk-Othmer Encyclopedia of Chemical Technology', and Patty’s Toxicology, 6th Edition, (peer reviewed handbook data), the oral LD50 for rat is 200 mg/kg bw. According to 'The condensed chemical dictionary', 8th edition (peer reviewed handbook data), the test item is highly toxic by ingestion and inhalation. Tolerance: 0.5ppm. According to 'The dictionary of substance and their effects', and 'Sax's Dangerous Properties of Indutrial Materials', 11th edition (peer reviewed handbook data), based on an acute oral toxicity study of the test item on quail (Coturnix coturnix), the oral LD50 for quail is 133 mg/kg bw. According to 'Patty’s Toxicology', 6th edition (peer reviewed handbook data), the oral LD50 for mice is 50 mg/kg bw. As the preferred species for acute oral toxicity studies is the rat, the key value is considered to be 200 mg/kg bw, based on the available information.
Acute Inhalatory Toxicity: No study was available. Supporting data: According to handbook data, a tolerance of 0.5 ppm in humans has been reported.
Acute Dermal Toxicity: Supporting study: According to 'Patty's
Toxicology', 6th ed., dermal absorption in guinea pigs occurs
readily for the test item, as indicated by an approximate LD50
of 500 mg/kg; deaths were accompanied by convulsions.
Acute toxicity, other routes: According to peer reviewed handbook data, the LC50 of the test item in mice is 35 mg/kg bw by intraperitoneal route, 70 mg/kg bw by intravenous route, and 23 mg/kg bw by intravenous route.
Justification for classification or non-classification
Based on the available information (oral LC50 between 50 and 300 mg/kg bw), the test item is classified as Acute Oral Category 3, H301, according to CLP Regulation (EC) No. 1272/2008.
Based on the available information (dermal LC50 between 200 and 1000 mg/kg bw), the test item is classified as Acute Dermal Category 3, H311, according to CLP Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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