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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Gross autopsy not reported, no information about GLP.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1992
Reference Type:
other: OECD SIDS
Title:
Unnamed
Year:
2001

Materials and methods

Principles of method if other than guideline:
10 male rats/concentration, head-only exposure, 6 concentrations, heated vapour was diluted with humidified and O2-enriched air and thus converted to a mixture of vapour and liquid aerosol, post exposure observation time: 14 days
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Purity 99.8%

Test animals

Species:
rat
Strain:
other: CD
Sex:
male

Administration / exposure

Route of administration:
other: inhalation: mixture of vapour and liquid aerosol
Type of inhalation exposure:
head only
Vehicle:
other: humidified and O2-enriched air
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
1.56, 1.83, 2.46, 2.64, 3.23, 3.33 mg/L
No. of animals per sex per dose:
10 male rats/concentration
Control animals:
no
Statistics:
LC50 value was calculated from statistically not significant regression (because mortality was not strictly dose-dependant).

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
ca. 3.2 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Mortality:
1.56 mg/L: 1 rat (day 5)
1.83 mg/L: 3 rats (2 on day 2, 1 on day 3)
2.46 mg/L: 2 rats (days 2 and 3)
2.64 mg/L: 10 rats (1 on day 0, 1 on day 1, 7 on day 2, 1 on day 3)
3.23 mg/L: 1 rat (day 2)
3.33 mg/L: 6 rats ( 1 on day 2, 2 on day 2, 2 on day 3, 1 on day 7)
Clinical signs:
other: During exposure: slight to moderate cyanosis, semi-prostration, lethargy and reddish brown nasal discharge to 24 hours, slight to moderate corneal opacity, tachypnea, some rats with partial hind-leg paralysis, abnormal arched-back posture. Post exposure:
Body weight:
Weight loss of 8 to 16% from 1 to 3 days with normal gains thereafter.

Applicant's summary and conclusion