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Diss Factsheets
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EC number: 200-529-9 | CAS number: 62-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Old studies showed that EDTA-CaNa2 is not irritating to skin and slightly irritating to eyes. These results were confirmed by other in vivo / in vitro skin and eye irritation studies with other metal EDTA chelates.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This study was conducted prior to GLP and limited information is available for the interpretation of study results; however, together with results of skin irritation studies with other metal chelates sufficient ifnormation is available for interpretation.
- Qualifier:
- according to guideline
- Guideline:
- other: CFR, Title 49, Section 173.240
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- Not specified in the report
- Duration of treatment / exposure:
- 4 hr
- Observation period:
- Not specified in the report
- Number of animals:
- Not specified in the report
- Details on study design:
- Not specified in the report
- Irritant / corrosive response data:
- Not specified in the report
- Other effects:
- Not specified in the report
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- As per EU classification calcium disodium is not irritating to skin when tested on rabbit.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1956
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This study was conducted prior to GLP and limited information is available for the interpretation of study results; however, together with results of eye irritation studies with other metal chelates sufficient ifnormation is available for interpretation.
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- Not specified in the report
- Vehicle:
- other: Unchanged diluted with water
- Controls:
- no
- Amount / concentration applied:
- 100 % - Unwashed
100 % - Washed with water
10 % - in water - Unwashed
10 % in water - Washed with water - Duration of treatment / exposure:
- Not specified in the report
- Observation period (in vivo):
- Not specified in the report
- Number of animals or in vitro replicates:
- Not specified in the report
- Details on study design:
- Not specified in the report
- Irritant / corrosive response data:
- 100 % - Unwashed : Moderate pain, slight conjuntival irritation, almost completely healed in 48 hrs.
100 % - Washed with water : Trace of pain, slight conjuntival irritation, almost completely healed in 2 days.
10 % - in water - Unwashed : Trace of pain, trace of conjuntival irritation, completely healed in 24 hrs.
10 % in water - Washed with water : Trace of pain, trace of conjuntival irritation, completely healed in 24 hrs. - Other effects:
- Not specified in the report
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of this study this test material is slightly irritating to eyes according to EU classification.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
This study was conducted prior to GLP and limited information is available for the interpretation of study results; however, together with results of skin irritation studies with other metal chelates sufficient ifnormation is available for interpretation.
Justification for selection of eye irritation endpoint:
This study was conducted prior to GLP and limited information is available for the interpretation of study results; however, together with results of eye irritation studies with other metal chelates sufficient ifnormation is available for interpretation.
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
Based on the absence of skin irritation and presence of slight eye irritation only, no classifcation is needed for skin and eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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