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EC number: 469-070-1 | CAS number: 17861-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 March to 25 March 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 17 December 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- 30 September 1996
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 469-070-1
- EC Name:
- -
- Cas Number:
- 17861-60-8
- Molecular formula:
- C9H26O2Si3
- IUPAC Name:
- 4-ethyl-2,2,4,6,6-pentamethyl-3,5-dioxa-2,4,6-trisilaheptane
- Test material form:
- liquid
- Details on test material:
- Other name: Baysilone TP 3886
Constituent 1
- Specific details on test material used for the study:
- Specific density: 828 g/L at 20°C
Storage condition: ambient temperature
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Crl: (WI) WU BR
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 7 - 8 weeks
- Weight at study initiation: 166 -180 g
- Fasting period before study: Prior to dosing, fasted overnight until approx. 4h after dosing
- Housing: maximum of six animals per macrolon cage
- Diet (e.g. ad libitum): standard laboratory diet ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: 13 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+/-3°C
- Humidity (%): 30 - 70%
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12h/12h
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Administered dose volume: 2.42 mL/kg bw
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations 1h, 4h after dosing, subsequently daily; weighing on day 0, 3, 7 and 14
- Necropsy of survivors performed: yes - Statistics:
- Not conducted
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- no mortality
- Clinical signs:
- other: no clinical signs (with exception of tremors in 3 animals 1 hour after dosing only)
- Gross pathology:
- no findings
Any other information on results incl. tables
Table 1: Acute oral toxicity of the test item in rats, individual and mean body weights, doses amounts applied and mortality
Animal no | Dose applied [mL] |
Body weights [g] recorded on day: | Mortality [dead/survived] |
|||
0 | 3 | 7 | 14 | |||
2000mg/kg bw (first group) | ||||||
41 | 0.43 | 180 | 195 | 197 | 207 | -- |
43 | 0.42 | 174 | 186 | 194 | 212 | -- |
45 | 0.41 | 169 | 186 | 189 | 201 | -- |
mean | 174 | 189 | 193 | 203 | 0/3 | |
2000mg/kg bw second group) | ||||||
59 | 0.4 | 166 | 183 | 187 | 198 | -- |
61 | 0.41 | 170 | 190 | 197 | 213 | -- |
63 | 0.43 | 180 | 196 | 205 | 210 | -- |
172 | 190 | 196 | 207 | 0/3 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 for oral toxicity to female rats was determined to be > 2000 mg/kg bw. The substance is not classified according to CLP criteria.
- Executive summary:
The acute oral (gavage) toxicitity of heptamethylethyltrisiloxane was investigated in female Wistar derived rats at a dose level of 2000 mg/kg bw followed by a 14 day observation period. The test substance was dosed undiluted. There were no deaths at 2000 mg/kg bw, therefore no further testing was required. There were no treatment related clinical signs, and all animals gained bodyweight during the observation period. Examination at necropsy revealed no effects of the test substance.
The acute oral median lethal dose (LD50) of heptamethylethyltrisiloxane in rats was found to be greater than 2000 mg/kg bw therefore the substance is not classified according to CLP criteria.
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