Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-007-1 | CAS number: 7783-54-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP and non-guideline compliant
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute inhalation toxicology and proposed emergency exposure limits of nitrogen trifluoride
- Author:
- Vernot, E. H., Haun, C. C. MacEwen, J. D. & Egan, G. F.
- Year:
- 1 973
- Bibliographic source:
- Toxicology and applied pharamacology, 26, pp 1-13
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Study involved exposing several species of animal in NF3 for various times in order to determine LC50 values for 15, 30 and 60 mins
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Reference substance name:
- Nitrogen trifluoride
- EC Number:
- 232-007-1
- EC Name:
- Nitrogen trifluoride
- Cas Number:
- 7783-54-2
- Molecular formula:
- F3N
- IUPAC Name:
- trifluoroamine
- Test material form:
- gas
Constituent 1
Test animals
- Species:
- other: rat ,mice, monkey, dog
- Strain:
- other: SD, ICR, rhesus, beagle
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Male SD and ICR mice were exposed (whole body) in a 30L bell jar chamber (10/gp of the same species). NF3 was introduced into the air stream prior to entry into a duplicate chamber which was used to establish contaminant concentrations. Air flow was fixed at 30 L/minute.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 15 - ca. 60 min
- Concentrations:
- Refer to results section
- No. of animals per sex per dose:
- 10/gp
- Control animals:
- no
- Details on study design:
- Animals surviving the exposure were held up to 2 weeks to include delayed deaths.
- Statistics:
- LC50 calculations were made by computerised version of the probit method of Finney.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 6 700 ppm
- 95% CL:
- ca. 6 130 - ca. 7 320
- Exp. duration:
- 60 min
- Remarks on result:
- other: rat
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 3 350 ppm
- Based on:
- other: time adjusted
- Exp. duration:
- 4 h
- Remarks on result:
- other: rat
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 7 500 ppm
- 95% CL:
- ca. 6 800 - ca. 8 280
- Exp. duration:
- 60 min
- Remarks on result:
- other: mouse
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 3 700 ppm
- Based on:
- other: time adjusted
- Exp. duration:
- 4 h
- Remarks on result:
- other: mouse
Any other information on results incl. tables
Table 7.2.2/01-1: Mortality in rats and mice exposed to NF3 for 60 minutes
Concentration (ppm) |
Mortality |
|
Mean |
Range |
|
RAT |
||
4118 |
4018 – 4428 |
0/10 |
5117 |
5002 – 5298 |
1/10 |
6121 |
5986 – 6232 |
4/10 |
7190 |
7134 – 7257 |
5/10 |
8204 |
8036 – 8282 |
9/10 |
LC50: 6700 ppm (6130 – 7320) |
||
MOUSE |
||
4112 |
3854 - 4264 |
0/10 |
6469 |
6297 – 6560 |
3/10 |
7150 |
6888 – 7544 |
4/10 |
8200 |
8150 – 8250 |
6/10 |
12218 |
12136 – 12300 |
10/10 |
LC50: 7500 ppm (6800 – 8280) |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.