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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- >= 0.89 - <= 1.77 mg/L
- Temp.:
- 20 °C
- pH:
- >= 5.34 - <= 5.77
- Conclusions:
- In a GLP-study according to OECD Test Guideline 105, the water solubility of the registered substance was 0.89 – 1.77 mg/L at 20.0 ± 0.5 °C, hence the substance is slightly soluble (0.1-100 mg/L)
- Executive summary:
The solubility of CARDOLITE NC-513 in water was determined from the measured concentrations of DOC in the filtrated test solutions and the carbon content in the test item (79.07 %).
The preliminary study which is described in the guideline was not performed as water solubility of the test item was estimated as < 10 mg/L in a non-GLP pre-test (measured in a solution with the nominal concentration of the test item 100 mg/L).
In the first experiment, 50 – 1001 mg/L test item in water were used for the test. Eight individual flasks (1A – 1E and 2 – 4) were prepared. Five test vessels (flasks 1D (for sampling date 4 days), 1E (7 days) and 2 – 4) and the blank were set onto the shaking apparatus immediately. After 24 ± 2 hours, flask 1C (for the sampling point 72 h), after further 24 ± 2 hours, flask 1B (for the sampling point 48 h) and after further 24 ± 2 hours, flask 1A (for the sampling point 24 h) were set on the shaker and all flasks were shaken for further 24 ± 2 hours at room temperature (20.0 ± 0.5 °C). Then, flasks 1A – 1D were taken from the shaker and stored at 20.0 ± 0.5 °C for equilibration. Samples were taken, membrane filtrated (0.45 µm, PTFE) and analysed for TOC via TOC analyser. The measured values lay below the LOQ of the instrument (1.13 mg/L). Therefore, the samples were sent to the laboratory Henkel for the determination of DOC using TOC-L CSH analyser with LOQ of TOC 0.1 mg/L together with the filtrated solutions from flasks 1E and 2 – 4 on day 7. As in the blank value, 0.45 mg/L DOC concentration was measured and the deviation between flasks 1A – 1E was too high, the first experiment was not valid and the values were not used in the calculation of the test item concentration. It is presumed, that the vessels for the delivery were contaminated.
In the second experiment, the same procedure was performed. Equilibration time was considered as approx. four days, as the value which was measured on the following consecutive seventh day did not give different values.
All replicates showed poor correspondence (RSD of 38 %), as dependency of solubility on amount of the test item (nominal load) was perceived, but no linear dependency was observed.
The solubility of the test item CARDOLITE NC-513 in demineralised water lay in the range 0.89 – 1.77 mg/L at 20.0 ± 0.5 °C
for the following nominal concentration range of the test item in water: 50 – 1001 mg/L.
Reference
Description of key information
water solubility (determined using OECD 105, flask method; GLP): 0.89 – 1.77 mg/L at 20.0 ± 0.5 °C
Key value for chemical safety assessment
- Water solubility:
- 1.77 mg/L
- at the temperature of:
- 20 °C
Additional information
In a GLP-study according to OECD Test Guideline 105, the water solubility of the registered substance was 0.89 – 1.77 mg/L at 20.0 ± 0.5 °C
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