Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 248-433-6 | CAS number: 27375-52-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- R: QSAR Toolbox 2.3.0.1132 prediction for LD50 read across evaluation for 27375-52-6
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- QSAR Toolbox version 2.3
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide
- EC Number:
- 248-433-6
- EC Name:
- N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide
- Cas Number:
- 27375-52-6
- Molecular formula:
- C10H13NO4S
- IUPAC Name:
- N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide
- Details on test material:
- - Name of test material (as cited in study report): N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 225.802 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(S(=O)(=O)CCO)ccc(NC(C)=O)cc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= -0.907
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.0724
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in rat was estimated to be 2225.802 mg/kg of body weight. Acute oral toxicity of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide to rat indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide does not exhibits acute toxicity by the oral route.
- Executive summary:
The acute oral median lethal dose (LD50) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in rat was estimated to be 2225.802 mg/kg of body weight. Acute oral toxicity of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide to rat indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide does not exhibits acute toxicity by the oral route.
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