Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-402-9 | CAS number: 120-51-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Published study with limited details relating to methods. Study pre-dates adoption of regulatory test guidelines.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological investigation of compounds proposed for use as insect repellents. A. Local and systemic effects following topical skin application
- Author:
- Draize JH, Alvarez E & Whitesell MF
- Year:
- 1 947
- Bibliographic source:
- J Pharmac Exp Ther 3(26): 26-39
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Screening test
- GLP compliance:
- no
- Test type:
- other: Draize primary skin irritation screening test
- Limit test:
- yes
Test material
- Reference substance name:
- Benzyl benzoate
- EC Number:
- 204-402-9
- EC Name:
- Benzyl benzoate
- Cas Number:
- 120-51-4
- Molecular formula:
- C14H12O2
- IUPAC Name:
- benzyl benzoate
- Test material form:
- other: liquid
- Details on test material:
- No details provided in publication
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No details provided
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- No details provided for method of application
- Duration of exposure:
- Not specified in publication, normal exposure period in Draize method is 4 hours.
- Doses:
- 2.0 mL/kg bw
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Statistics:
- No data
Results and discussion
- Preliminary study:
- No information
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No deaths occurred
- Mortality:
- No mortality in skin irritation tests.
Benzyl benzoate displays a toxic threshold with a sharp demarcation at circa 2.0 mL/kg bw. Delayed deaths occurred following a single high dose topical application. Animals that died exhibited no clinical signs prior to death. - Clinical signs:
- other: No signs of systemic toxicity observed
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD50 of benzyl benzoate was found to be >2 mL/kg bw (~2000 mg/kg bw) under the conditions of this assay.
- Executive summary:
The acute dermal LD50 of benzyl benzoate was investigated in a screening assay in the rabbit and was found to be >2 mL/kg bw (~2000 mg/kg bw).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.