Registration Dossier
Registration Dossier
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EC number: 252-038-4 | CAS number: 34452-51-2
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Justification for type of information:
- see attached category justification
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Data source
Materials and methods
- GLP compliance:
- yes
Test material
- Reference substance name:
- Potassium mercaptoacetate
- EC Number:
- 252-038-4
- EC Name:
- Potassium mercaptoacetate
- Cas Number:
- 34452-51-2
- Molecular formula:
- C2H4O2S.K
- IUPAC Name:
- potassium sulfanylacetate
Constituent 1
Results and discussion
Percutaneous absorption
- Key result
- Time point:
- 30 min
- Dose:
- 165 mg/kg bw
- Parameter:
- percentage
- Absorption:
- ca. 1 %
- Remarks on result:
- other: rinsing after 30 min
Applicant's summary and conclusion
- Conclusions:
- Based on data for ATG, the cutaneous absorption of aqueous KTG solutions is expected to be ca. 1%.
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