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EC number: 203-539-1 | CAS number: 107-98-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study methodology followed was equivalent or similar to EU Method B.1 and in accordance with the Principles of GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-methoxypropan-2-ol
- EC Number:
- 203-539-1
- EC Name:
- 1-methoxypropan-2-ol
- Cas Number:
- 107-98-2
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 1-methoxypropan-2-ol
- Details on test material:
- - Name of test material (as cited in study report): Methyl proxitol
- Physical state: clear, colourless liquid
- Analytical purity: not specified in the report
- Impurities (identity and concentrations): not specified in the report
- Composition of test material, percentage of components: sec. methyl mono proxitol - 97.7%, prim. methyl mono proxitol - 2.06%, unknowns - 0.01%, propylene oxide - < 0.01%, methanol - 0.12%, water - 0.09%, acidity (as acetic acid) - 0.001%
- Isomers composition: not specified in the report
- Purity test date: not specified in the report
- Lot/batch No.: Indent 9200/9075
- Expiration date of the lot/batch:
- Expiration date of radiochemical substance (if radiolabelling):
- Stability under test conditions: stable as per infra-red spectra
- Storage condition of test material: stored in the dark at ambient temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River
- Age at study initiation: 9-11 weeks
- Weight at study initiation: 180-250 g (male) and 110-170 g (female)
- Fasting period before study: overnight fasting (18 hours)
- Housing: 2-3 rats/cage
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: not specified in the report
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25 °C
- Humidity (%): not specified in the report
- Air changes (per hr): not specified in the report
- Photoperiod (hrs dark / hrs light): 12 hours light:dark cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test material was administered undiluted.
- Doses:
- 2500, 3150, 3970 and 5000 mg/kg
- No. of animals per sex per dose:
- 5 males + 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: initial, day 7 and day 14
- Necropsy of survivors performed: yes - Statistics:
- probit analysis
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 277 mg/kg bw
- 95% CL:
- 3 478 - 5 572
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 739 mg/kg bw
- 95% CL:
- 2 573 - 7 986
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 016 mg/kg bw
- 95% CL:
- 3 503 - 4 915
- Mortality:
- Refer to Table 1 for further details.
- Clinical signs:
- other: Refer to Tables 2 and 3 for further details, rats in all the dose groups were overtly affected, the commonest clinical signs being gait abnormalities, chromodacryorrhoea and piloerection. The majority of the rats that died were comatose prior to death - i
- Gross pathology:
- Refer to Tables 2 and 3 for further details
- Other findings:
- - Organ weights: no data
- Histopathology: no data
- Potential target organs: no data
Any other information on results incl. tables
Table 1: Mortality Table
Dose (mg/kg) | Cummulative mortality (14 days) | ||
Male | Female | Total | |
2500 | 1/5 | 0/5 | 1/10 |
3150 | 1/5 | 0/5 | 1/10 |
3970 | 3/5 | 2/5 | 5/10 |
5000 | 4/5 | 4/5 | 8/10 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of the study, the LD50 for methyl proxitol to rats (combined) was 4016 mg/kg (3503-4915 mg/kg), for females was 4277 mg/kg (3478-5572 mg/kg) and for males was 3739 mg/kg (2573-7986 mg/kg)
- Executive summary:
The acute oral toxicity of methyl proxitol was evaluated in groups of rats (5 males + 5 females) at doses of 2500, 3150, 3970 and 5000 mg/kg. Mortality was observed in all the dose groups. Rats in all the dose groups were overtly affected, the commonest clinical signs being gait abnormalities, chromodacryorrhoea and piloerection. The majority of the rats that died were comatose prior to death - in some cases they were unconscious for 48 hours or more before death. Four rats from the 3970 mg/kg dose group and one male from the 5000 mg/kg dose group were comatose for part or all of day 2 but recovered. All surviving animals had gained weight relative to their day 0 body weights by the end of the 14-day observation period. Based on the results of the study, the LD50 for methyl proxitol to rats (combined) was 4016 mg/kg (3503-4915 mg/kg), for females was 4277 mg/kg (3478-5572 mg/kg) and for males was 3739 mg/kg (2573-7986 mg/kg)
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