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EC number: 215-684-8 | CAS number: 1344-00-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Nanomaterial dustiness
Administrative data
- Endpoint:
- nanomaterial dustiness
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- appearance / physical state / colour
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: visual examination in a guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- visual inspection
- GLP compliance:
- no
- Physical state at 20°C and 1013 hPa:
- solid
- Key result
- Form:
- solid: particulate/powder
- Remarks:
- fine powder
- Colour:
- white
- Substance type:
- inorganic
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
- Principles of method if other than guideline:
- The determination of the dustiness based on a laser diffraction analysis of the test substance according to
- Dustiness equivalent of synthetic amorphous silica (CAS-No:7631-86-9) for the purpose of substance registration and evaluation within REACH (2018) by Prof. Dr.- Ing. Habil. Michael Stintz
Weak dry dispersion method GRADIS/L and determination of particle size distribution by laser diffraction measurement according to OECD Test Guideline 110 (1981) and ISO 13320 (2009).
The health relevant volume-weighted fractions according to EN481:1993 with an aerodynamic cut-off diameter of 100 µm and 37 µm were calculated based on these measured values and the tamped density. The tamped density was assumed to be the effective particle density at weak dry dispersion intensity. - GLP compliance:
- no
- Type of method:
- other: weak dry dispersion combined with laser diffraction
Test material
- Reference substance name:
- Silicic acid, aluminum sodium salt
- EC Number:
- 215-684-8
- EC Name:
- Silicic acid, aluminum sodium salt
- Cas Number:
- 1344-00-9
- Molecular formula:
- nSiO2*mAl2O3*zNa2O n = 2-4; m = 0.12-3.20; z = 0.11-4.5
- IUPAC Name:
- aluminium(3+) sodium bis(oxosilanebis(olate))
- Test material form:
- solid: nanoform, no surface treatment
- Remarks:
- crystalline-free
Constituent 1
Data gathering
- Instruments:
- HELOS/KR
A laser diffraction spectrometer (Modell HELOS/KR, Sympatec GmbH, Clausthal-Zellerfeld, Germany) according to ISO 13320:2009 with a He-Ne-laser (laser wavelength of 632.8 nm). Four different size ranges (R1: 0.1 µm- 35 µm, R3: 0.5 µm-175 µm; R5: 0.5 µm- 875 µm; R7: 0.5 µm – 3500 µm) could be used to determine volume-weighted particle size distributions. The FRAUNHOFER theory was used for the evaluation of the detected signals. From the diffraction pattern the particle size distribution according to the Fraunhofer evaluation (no refractive index is necessary) was calculated.
Particle Analyzer: HELOS KR of company Sympatec
Observed range: 0.1 µm to 3500 µm
Software: PAQXOS 3.0.4
GRADIS/L (weak dispersion)
The sedimentation shaft GRADIS/L (Sympatec GmbH, Clausthal-Zellerfeld, Germany) was a dry dispersion unit that was developed for the operation in combination with the laser diffraction spectrometer HELOS KR. The powder material feeding into the head of the sedimentation shaft could be realized by different dosing systems (e.g. vibrating chute called VIBIR/L).
During the fall from a drop height of 500 mm, the material impinged onto two sloping planes (inclination of 45°) within the GRADIS. Next to the weak dispersion, which results from the fall-induced drag force, the powder dispersion was thus additionally affected by particle-wall impaction. - Calibration:
- Verification and calibration
Every measuring cell was checked with the corresponding reference substance.
As different ranges (Range 5 and Range 7) could be used, the different ranges were also checked with the corresponding reference substance.
The reference substances were certified standards of the company Sympatec for testing the device.
Following ranges were used for following test methods:
Range 5 and 7: reference substance SiC-P80'11
Results and discussion
Dustiness indexopen allclose all
- Mean:
- 21 531 mg/kg
- St. dev.:
- 1 782 mg/kg
- Remarks on result:
- other: inhalable fraction, calculated until cut-off 100 µm
- Mean:
- 4 mg/kg
- St. dev.:
- 1 mg/kg
- Remarks on result:
- other: thoracic fraction
- Mean:
- 0 mg/kg
- St. dev.:
- 0 mg/kg
- Remarks on result:
- other: alveolar fraction
Any other information on results incl. tables
The determination of the dustiness was performed based on laser
diffraction analyses by the weak dry dispersion GRADIS/L and the tamped
density. With these measured values the health relevant volume-weighted
fractions according to EN 481:1993 were determined with an aerodynamic
cut-off diameter off 100 µm.
For comparison with results of the standardised dustiness methods
according to EN 15051-1:2013, the inhalable fraction of the substitute
method was calculated additionally until the corresponding
technological-limited aerodynamic cut-off diameters of 37 µm (in the
case of the method EN 15051-3:2013) and not until the aerodynamic
cut-off diameter of 100 µm based on EN 481:1993.
With the test method GRADIS/L and the tamped density the dust behaviour
or the dust formation of the sample after a single drop, i.e. after
normal handling, is shown.
Mean value of the singular fractions until selected aerodynamic cut-off 100 µm (calculated from laser diffraction analysis, measurements 1 – 3):
|
Inhalable [mg/kg] |
Thoracic [mg/kg] |
Alveolar [mg/kg] |
Mean value |
21531 |
4 |
0 |
Standard deviation |
1782 |
1 |
0 |
RSD |
8.28 % |
17.78 % |
18.85 % |
Mean value of the singular fractions until selected aerodynamic cut-off 37 µm (calculated from laser diffraction analysis, measurements 1 – 3):
|
Inhalable [mg/kg] |
Thoracic [mg/kg] |
Alveolar [mg/kg] |
Mean value |
436 |
2 |
0 |
Standard deviation |
87 |
0 |
0 |
RSD |
19.92 % |
19.92 % |
19.92 % |
As the relative standard deviation of the singular measurements with the weak dry dispersion GRADIS did not exceed 5 % the study can be considered valid. The relative standard deviation of the determination of the health fractions was high due to the fact that the agglomeration behaviour of the sample can vary.
Average volume weighted particle size distribution (of measurements 1 – 3) of test method GRADIS/L:
|
D10 [µm] |
D50 [µm] |
D90 [µm] |
Mean value |
232.9 |
449.18 |
706.81 |
Standard deviation |
4.92 |
11.23 |
34.45 |
Width |
227.45 – 237.02 |
440.00 – 461.70 |
685.64 – 746.56 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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