Nonan-1-ol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1986

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

Individual result were not reported.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1992

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Nonan-1-ol

EC Number:

205-583-7

EC Name:

Nonan-1-ol

Cas Number:

143-08-8

Molecular formula:

C9H20O

IUPAC Name:

nonan-1-ol

Details on test material:

No data.

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

No data.

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

other: undiluted (and as 50% solution in PEG400)

Controls:

not specified

Amount / concentration applied:

TEST MATERIAL

- Concentration (if solution): Undiluted or 50% in PEG.

Duration of treatment / exposure:

4 hour(s)

Observation period:

72 hours

Number of animals:

6

Details on study design:

TEST SITE

- Application under exposure chamber of 6cm2.

REMOVAL OF TEST SUBSTANCE

-Not reported.

SCORING SYSTEM: Draize

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Remarks:

Undiluted test substance

Basis:

mean

Time point:

24/48/72 h

Score:

2.2

Max. score:

4

Reversibility:

not reversible

Remarks on result:

probability of mild irritation

Remarks:

individual animal scores were not given

Results 2

Irritation parameter:

edema score

Remarks:

Undiluted test substance

Basis:

mean

Time point:

24/48/72 h

Score:

0

Max. score:

4

Remarks on result:

no indication of irritation

Remarks:

individual animal scores were not given

Results 3

Irritation parameter:

erythema score

Remarks:

50% dilution of test substance

Basis:

mean

Time point:

24/48/72 h

Score:

1.9

Max. score:

4

Reversibility:

not reversible

Remarks on result:

probability of mild irritation

Remarks:

individual animal scores were not given

Results 4

Irritation parameter:

edema score

Remarks:

50% dilution of test substance

Basis:

mean

Time point:

24/48/72 h

Score:

0.2

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: individual animal scores were not given

Irritant / corrosive response data:

See table 1 and 2.

Other effects:

None reported.

Any other information on results incl. tables

Table 1: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test. Undiluted test substance.

Score at time point / Reversibility	Erythema	Edema
	Max. score: 4	Max. score: 2
60 min (group mean)	0.8	0
24 h (group mean)	1.8	0
48 h (group mean)	2.4	0
72 h (group mean)	2.4	0
Average 24h, 48h, 72h	2.2	0
Reversibility*)	n	n
Average time (unit) for reversion	-	-

*) Reversibility: c. = completely reversible; n.c. = not completely reversible; n. = not reversible#

Table 2: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test. 50%nonanolin PEG400.

Score at time point / Reversibility	Erythema	Edema
	Max. score: 4	Max. score: 2
60 min (group mean)	0.8	0.2
24 h (group mean)	1.8	0.2
48 h (group mean)	2.0	0.4
72 h (group mean)	2.0	0
Average 24h, 48h, 72h	1.9	0.2
Reversibility*)	n	n
Average time (unit) for reversion	-	-

 

*) Reversibility: c. = completely reversible; n.c. = not completely reversible; n. = not reversible

 (individual animal scores were not reported)

 

 

Applicant's summary and conclusion

Interpretation of results:

Category 3 (mild irritant) based on GHS criteria

Conclusions:

A mean erythema score of 2.2 was determined in a reliable study conducted according to an appropriate test protocol. The study was not in compliance with GLP.