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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 January 2018 to 27 February 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 2009
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: Knudsen cell
- Key result
- Test no.:
- #1
- Temp.:
- 20 °C
- Vapour pressure:
- 0.003 Pa
- Key result
- Test no.:
- #1
- Temp.:
- 25 °C
- Vapour pressure:
- 0.004 Pa
- Conclusions:
- Under the conditions of this study, the vapour pressure of the test material at 20 °C was 3.25 x10^-03 Pa and at 25 °C was 3.73 x10^-03 Pa.
- Executive summary:
The vapour pressure of the test material was investigated in accordance with the standardised guidelines OECD 104 and EU Method A.4, under GLP conditions.
The vapour pressure was determined using the effusion method (weight loss). Vapour pressure was examined at six different temperatures. Three temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (p).
The graph 1/T vs. log (p) showed a straight line with a correlation coefficient of -0.9988. For the test material the vapour pressures at 20 °C and at 25 °C were calculated from the regression equation.
Under the conditions of this study, the vapour pressure of the test material at 20 °C was 3.25 x10^-03 Pa and at 25 °C was 3.73 x10^-03 Pa.
Reference
Sample Weights
Knudsen-cell 1: 0.64935 g test material
Knudsen-cell 2: 0.69900 g test material
Knudsen-cell 3: 0.67754 g test material
Knudsen-cell 4: 0.65529 g test material
Observations
30 °C: At the first measurement of experiment 1, all cells were slightly contaminated. Therefore, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, this measurement was not used for calculations.
60 °C: At the second measurement of experiment 3, all cells were slightly contaminated. Therefore, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, this measurement was not used for calculations.
60 °C: At the third measurement of experiment 3, cell 1 and 4 were slightly contaminated. Therefore, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, this measurement was not used for calculations.
Calculation Results
Experiment 1:
Temperature: 303.2 K; 30.0 °C
Mean of measured values: 4.223E-03
Standard deviation: 2.825E-06; RSD: 0.1 %
Experiment 2:
Temperature: 318.2 K; 45.0 °C
Mean of measured values: 6.321E-03
Standard deviation: 1.802E-03; RSD: 28.5 %
Experiment 3:
Temperature: 333.2 K; 60.0 °C
Mean of measured values: 8.612E-03
Standard deviation: 2.495E-03; RSD: 29.0 %
Evaluation
The measured values for temperature and vapour pressure were evaluated as follows:
Table 1: Evaluation of Calculated Values
Temperature (K) |
Mean p (Pa) |
1/T (1/K) |
log p (log Pa) |
303.2 |
4.22E-03 |
3.2982E-03 |
-2.3744 |
318.2 |
6.32E-03 |
3.1427E-03 |
-2.1992 |
333.2 |
8.61E-03 |
3.0012E-03 |
-2.0649 |
- A graph with log p vs. 1/T was plotted. Since the values were correlated by a linear relation, the data could be fitted by linear regression.
Slope: -1043.6
Intercept: 1.0719
Correlation Coefficient (r): -0.9988
Coefficient of Determination (r^2): 0.9976
Test Material
- The following vapour pressures were determined experimentally and considered as valid (mean and standard deviation given):
Table 1: Experimentally Determined Vapour Pressures
Temperature (°C) |
Temperature (K) |
Vapour Pressure (Pa) |
Standard Deviation (Pa) |
RSD p (%) |
30.0 |
303.2 |
0.00422 |
0.00000283 |
0.1 % |
45.0 |
318.2 |
0.00632 |
0.00180 |
28.5 % |
60.6 |
333.2 |
0.00861 |
0.00249 |
29.0 % |
RSD = Relative standard deviation.
- The following vapour pressures at 20 and 25 °C were calculated from the regression equation:
Vapour pressure at 20 °C: 3.25 x10^-03 Pa
Vapour pressure at 25 °C: 3.73 x10^-03 Pa
- The linear regression of log p vs. 1/T gave a correlation coefficient r of - 0.9988, showing good repeatability and precision. Therefore, the determination is considered as valid.
Positive Control
- For Diethylphthalate the following vapour pressure was determined and compared with recommended value:
Vapour pressure (positive control) at 30 °C: 1.60x10^-1 Pa
Criterion for the vapour pressure of the positive control at 30 °C: 0.44x10^-1 - 2.44x10^-1 Pa
- The vapour pressure met the validity criteria. Therefore the study can be considered as valid.
Discussion
- The vapour pressure of the test material was determined at six different temperatures (30, 45, 60, 75, 90 and 105 °C) according to OECD 104 resp. EU A.4 using the effusion method (weight loss).
- Experiment 4 - 6 (nominal temperature 75 - 105 °C) showed no reproducible weight loss. When visible contaminations, caused by explosive evaporation of the test material, were observed, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, these measurements were not used for calculations.
- Three experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good reproducibility, giving relative standard deviations of less than 30 % (limit value from the guideline 30 %) and good correlation. Therefore, the result of the test can be considered valid.
Description of key information
Under the conditions of this study, the vapour pressure of the test material at 20 °C was 3.25 x10^-03 Pa and at 25 °C was 3.73 x10^-03 Pa.
Key value for chemical safety assessment
- Vapour pressure:
- 0.003 Pa
- at the temperature of:
- 20 °C
Additional information
The vapour pressure of the test material was investigated in accordance with the standardised guidelines OECD 104 and EU Method A.4, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The vapour pressure was determined using the effusion method (weight loss). Vapour pressure was examined at six different temperatures. Three temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (p).
The graph 1/T vs. log (p) showed a straight line with a correlation coefficient of -0.9988. For the test material the vapour pressures at 20 °C and at 25 °C were calculated from the regression equation.
Under the conditions of this study, the vapour pressure of the test material at 20 °C was 3.25 x10^-03 Pa and at 25 °C was 3.73 x10^-03 Pa.
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