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EC number: 605-399-0 | CAS number: 165252-70-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12/10/1995 - 09/06/1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were analysed after incubation for 0.25, 2.4, 24, 95/96, 118/120 and 170 hours.
- Buffers:
- Buffer solutions were created using chemicals described in Table 1 in order to produce solutions of pH 4.0, 7.0, 9.0, 11.0, and 13.0. The test solutions were adjusted to within ± 0.05 pH of the desired value before being purged with nitrogen.
- Duration:
- 170 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.85 mg/L
- Duration:
- 170 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.91 mg/L
- Duration:
- 170 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 2.05 mg/L
- Duration:
- 120 h
- pH:
- 11
- Temp.:
- 50 °C
- Initial conc. measured:
- 2.1 mg/L
- Duration:
- 96 h
- pH:
- 13
- Temp.:
- 50 °C
- Initial conc. measured:
- 2.05 mg/L
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- no
- Statistical methods:
- not reported
- Preliminary study:
- The preliminary test was the only test reported in the study as less than 10% degradation was observed at pH 4, 7 and 9 in the preliminary test.
The results are summarised in Table 2. There was no significant change in the concentration of dinotefuran when incubated at pH 4, pH 7 or pH 9 at 50ºC. Less than 10% degradation was observed.
As there was no degradation at lower pH values, no rate constants were calculated. It was possible to calculate rate constants at pH 11 and 13.
Ln Ct (pH 11 and 50ºC) = 0.710-1.55 x10¯²t,
Ln Ct (pH 13 and 50ºC) = 0.751-1.65 x10¯²t
There was less than 10% degradation of dinotefuran over 170 hours when incubated at pH 4, pH7 or pH9 at 50ºC. The half- life at pH 11 was 45 hours. The half-life at pH 13 was 4.2 hours.
There were no significant transformation products at the required pH values. The only transformation product observed in any significant amounts was found at pH 11 and 13 and identified as 1-methyl-3-(tetrahydro-3-furylmethyl)urea (UF) by co-chromatography and LC-MS/MS with reference standard. - Transformation products:
- yes
- No.:
- #1
- Remarks on result:
- other: Dinotefuran was hydrolytically stable at pH 4,7 and 9 at 50ºC
- Validity criteria fulfilled:
- yes
- Conclusions:
- Dinotefuran can be considered as stable to hydrolysis under environmentally relevant conditions with a half life greater than one year as it was stable at pH 4, 7 and 9 at 50ºC. At pH 11 and 13 and 50ºC, hydrolysis to 1-methyl-3-(tetrahydro-3-furylmethyl) urea (UF) was observed with half lives of 45 hours and 4.2 hours respectively. Although not required by the guideline, degradate UF was identified by LC-MS/MS.
Reference
Table 1: Type and composition of buffer solutions (specify kind of water if necessary)
pH |
Type of buffer (final molarity) |
Composition |
4 |
Not stated |
Disodium hydrogen orthophosphate dodecahydrate (13.8g) and citric acid monohydrate (6.45g) were dissolved in purified water (950ml) and the pH adjusted to 4.0 with 1M hydrochloric acid. The volume was adjusted to 1000 ml with purified water. |
7 |
Not stated |
Potassium dihydrogen orthophosphate (3.4g) was dissolved in purified water (950ml). 1M sodium hydroxide (15ml) was added and the pH adjusted to 7.0 with 1M hydrochloric acid. The volume was adjusted to 1000ml with purified water. |
9 |
Not stated |
Disodium tetraborate decahydrate (16.6g) and potassium dihydrogen orthophosphate (1.80g) were dissolved in purified water (950ml) and the pH adjusted to 9.0with 1M hydrochloric acid. The volume was adjusted to 1000ml with purified water. |
11 |
Not stated |
Glycine (7.54g) and sodium chloride (5.84g) were dissolved in 1000 ml of purified water (Solution A). Sodium hydroxide (2.04g) was dissolved in 500ml of purified water (Solution B). Portions of Solution A and Solution B (51ml and 49ml respectively) were mixed thoroughly. |
13 |
Not stated |
Glycine (7.54g) and sodium chloride (5.84g) were dissolved in 1000ml of purified water (Solution A). Sodium hydroxide (2.04g) was dissolved in 500ml of purified water (Solution B). Portions of Solution A and Solution B (7.5 ml and 92.5 ml respectively) were mixed thoroughly. |
Table 2: Concentration (mg/l) of dinotefuran (parent compound) with time at various pH values
|
Days of incubation |
|||||
0 |
2.4 |
24 |
95/96 |
118/120 |
170 |
|
pH 4 |
1.85 |
1.85 |
1.87 |
1.83 |
1.84 |
1.83 |
pH 7 |
1.91 |
1.89 |
1.91 |
|
1.88 |
1.84 |
pH 9 |
2.05 |
2.07 |
2.01 |
|
1.93 |
1.84 |
pH 11 |
2.10 |
1.97 |
1.34 |
0.46 |
0.32 |
|
pH 13 |
2.05 |
1.48 |
0.04 |
|
|
|
Description of key information
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 7 d
- at the temperature of:
- 50 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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