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Diss Factsheets
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EC number: 217-316-1 | CAS number: 1809-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- irritation parameters not recorded at 48 hours; test performed on both intact and abraded skin
- GLP compliance:
- no
Test material
- Reference substance name:
- Dibutyl phosphonate
- EC Number:
- 217-316-1
- EC Name:
- Dibutyl phosphonate
- Cas Number:
- 1809-19-4
- Molecular formula:
- C8H19O3P
- IUPAC Name:
- dibutyl phosphonate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: two test sites: one was abraded and the other intact
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 24 and 72 hours
- Observation period:
- 72 hours
- Number of animals:
- 6 rabbits
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: Intact skin, average of 6 rabbits
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: Abraded skin - Average of 6 rabbits
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 2.9
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: Intact skin - Average from 6 rabbits
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 2.8
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: Abraded skin - Average of 6 rabbits
- Irritant / corrosive response data:
- Mean (24, 48, 72 hour) scores, with 48 hour score estimated based on the worse of either 24 or 72 hour scores, using a worst case scenario approach):
ERYTHEMA:
- Animals 1-6 (all): 4 (at all time points on all animals, on both intact and abraded skin)
OEDEMA:
- Animals 1, 2, 5, 6: 3 at 24 hours; 2 at 72 hours (both intact and abraded skin)
- Animals 3, 4: 4 at 24 hours; 2 at 72 hours (both intact and abraded skin)
Any other information on results incl. tables
Table: Results for erythema and oedema.
Erythema formation | 1 | 2 | 3 | 4 | 5 | 6 | |
Intact skin | 24 h | 4 | 4 | 4 | 4 | 4 | 4 |
72 h | 4 | 4 | 4 | 4 | 4 | 4 | |
Abraded skin | 24 h | 4 | 4 | 4 | 4 | 4 | 4 |
72 h | 4 | 4 | 4 | 4 | 4 | 4 | |
Oedema formation | 1 | 2 | 3 | 4 | 5 | 6 | |
Intact skin | 24 h | 3 | 3 | 4 | 4 | 3 | 3 |
72 h | 2 | 2 | 2 | 2 | 2 | 2 | |
Abraded skin | 24 h | 3 | 3 | 4 | 4 | 3 | 3 |
72 h | 2 | 2 | 2 | 2 | 2 | 2 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Category 2 (Skin irritant) based on CLP Regulation (EC) no. 1272/2008
- Conclusions:
- Severely irritating to rabbit skin
Erythema score: 4.0 (6 animals, at both 24 & 72 h, intact skin)
Oedema score: 3.33 at 24 hours (mean, 6 animals, intact skin) and 2.0 (6 animals, 72 h, intact skin) - Executive summary:
The skin irritation potential of the substance was evaluated in an in vivo experimental study similar to the OECD Guideline 404. The test item was applied as is to both an intact site and an abraded site of six New Zealand white rabbits, and the sites were monitored for erythema and oedema according to the Draize scale, at 24 and 72 hours after application.
All six animals demonstrated an erythema score of 4.0 at both the 24 hour and the 72 hour monitoring of both the intact and the abraded skin sites. Four out of the six animals demonstrated an oedema score of 3.0 at 24 hours on both the intact and abraded sites; the remaining two animals had a score of 4.0 at the same sites and times. At 72 hours, all six animals demonstrated an oedema score of 2.0 at both the intact and abraded sites. Reversibility of erythema and oedema was not monitored beyond 72 hours in this study. Based on these findings, the substance is considered irritating to rabbit skin.
For evaluation using the CLP regulation, it is necessary to calculate the mean erythema and oedema scores at 24, 48 and 72 hours for each animal at the intact site only. As no data for the 48 hour interval was recorded in this study, the mean was calculated using a worst-case approach, whereby the more severe of the 24 or 72 hour scores in place of the 48 hour score. The mean (24/48/72 h) erythema scores were 4.0 for all 6 animals; the mean (24/48/72 h) oedema scores were 2.67 for 4 animals, and 3.33 for 2 animals.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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